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Phosphodiesterase 4D, cAMP-specific
Protein PDE4D PDB 1mkd.png
PDB rendering based on 1mkd.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600129 MGI99555 HomoloGene129755 ChEMBL: 288 GeneCards: PDE4D Gene
EC number
RNA expression pattern
PBB GE PDE4D 210837 s at tn.png
PBB GE PDE4D 210836 x at tn.png
PBB GE PDE4D 211840 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5144 238871
Ensembl ENSG00000113448 ENSMUSG00000021699
UniProt Q08499 Q01063
RefSeq (mRNA) NM_001104631 NM_011056
RefSeq (protein) NP_001098101 NP_035186
Location (UCSC) Chr 5:
58.26 – 59.82 Mb
Chr 13:
108.45 – 109.95 Mb
PubMed search [1] [2]

cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene.

The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).[supplied by OMIM][1]


PDE4D has been shown to interact with myomegalin[2] and GNB2L1.[3][4]

Clinical relevance[edit]

Mutations in this gene have been associated to cases od acrodysostosis.[5]

This is the subtype of PDE4 that appears to be involved in the emetic and antidepressant effects of PDE4 inhibitors.[6]


  1. ^ "Entrez Gene: PDE4D phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)". 
  2. ^ Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Coletti D, Onuffer J, Jin SL, Conti M (April 2001). "Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". J. Biol. Chem. 276 (14): 11189–98. doi:10.1074/jbc.M006546200. PMID 11134006. 
  3. ^ Yarwood SJ, Steele MR, Scotland G, Houslay MD, Bolger GB (May 1999). "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform". J. Biol. Chem. 274 (21): 14909–17. doi:10.1074/jbc.274.21.14909. PMID 10329691. 
  4. ^ Steele MR, McCahill A, Thompson DS, MacKenzie C, Isaacs NW, Houslay MD, Bolger GB (July 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cell. Signal. 13 (7): 507–13. doi:10.1016/S0898-6568(01)00167-X. PMID 11516626. 
  5. ^ Michot, C; Le Goff, C, Goldenberg, A, Abhyankar, A, Klein, C, Kinning, E, Guerrot, AM, Flahaut, P, Duncombe, A, Baujat, G, Lyonnet, S, Thalassinos, C, Nitschke, P, Casanova, JL, Le Merrer, M, Munnich, A, Cormier-Daire, V (Mar 28, 2012). "Exome Sequencing Identifies PDE4D Mutations as Another Cause of Acrodysostosis.". American Journal of Human Genetics 90 (4): 740–5. doi:10.1016/j.ajhg.2012.03.003. PMID 22464250. 
  6. ^ Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs". Current Pharmaceutical Design 15 (14): 1688–1698. doi:10.2174/138161209788168092. PMID 19442182. 

Further reading[edit]