PDGFB

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Platelet-derived growth factor beta polypeptide
Protein PDGFB PDB 1pdg.png
PDB rendering based on 1pdg.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PDGFB ; IBGC5; PDGF-2; PDGF2; SIS; SSV; c-sis
External IDs OMIM190040 MGI97528 HomoloGene74303 GeneCards: PDGFB Gene
RNA expression pattern
PBB GE PDGFB 204200 s at tn.png
PBB GE PDGFB 216061 x at tn.png
PBB GE PDGFB 217112 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5155 18591
Ensembl ENSG00000100311 ENSMUSG00000000489
UniProt P01127 P31240
RefSeq (mRNA) NM_002608 NM_011057
RefSeq (protein) NP_002599 NP_035187
Location (UCSC) Chr 22:
39.62 – 39.64 Mb
Chr 15:
80 – 80.01 Mb
PubMed search [1] [2]

Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene.[1][2]

Function[edit]

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha (PDGFA) polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds.

Clinical significance[edit]

Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.[3]

See also[edit]

References[edit]

  1. ^ Ratner L, Josephs SF, Jarrett R, Reitz MS, Wong-Staal F (Sep 1985). "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor". Nucleic Acids Res 13 (14): 5007–18. doi:10.1093/nar/13.14.5007. PMC 321845. PMID 2991848. 
  2. ^ Clements JM, Bawden LJ, Bloxidge RE, Catlin G, Cook AL, Craig S, Drummond AH, Edwards RM, Fallon A, Green DR (Jan 1992). "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation". EMBO J 10 (13): 4113–20. PMC 453161. PMID 1661670. 
  3. ^ "Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)". 

Further reading[edit]

  • Kurup S, Abramsson A, Li JP, Lindahl U, Kjellen L, Betsholtz C, Gerhardt H, Spillmann D (2006). "Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment". Biochem. Soc. Trans. 34 (Pt 3): 454–5. doi:10.1042/BST0340454. PMID 16709185.