PDGFD

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Platelet derived growth factor D
Identifiers
Symbols PDGFD ; IEGF; SCDGF-B; SCDGFB
External IDs OMIM609673 MGI1919035 HomoloGene11875 GeneCards: PDGFD Gene
RNA expression pattern
PBB GE PDGFD 219304 s at tn.png
PBB GE PDGFD gnf1h09263 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 80310 71785
Ensembl ENSG00000170962 ENSMUSG00000032006
UniProt Q9GZP0 Q925I7
RefSeq (mRNA) NM_025208 NM_027924
RefSeq (protein) NP_079484 NP_082200
Location (UCSC) Chr 11:
103.78 – 104.04 Mb
Chr 9:
6.17 – 6.38 Mb
PubMed search [1] [2]

Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene.[1][2][3]

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.[3]

References[edit]

  1. ^ Hamada T, Ui-Tei K, Imaki J, Miyata Y (Feb 2001). "Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein". Biochem Biophys Res Commun 280 (3): 733–7. doi:10.1006/bbrc.2000.4187. PMID 11162582. 
  2. ^ LaRochelle WJ, Jeffers M, Corvalan JR, Jia XC, Feng X, Vanegas S, Vickroy JD, Yang XD, Chen F, Gazit G, Mayotte J, Macaluso J, Rittman B, Wu F, Dhanabal M, Herrmann J, Lichenstein HS (Apr 2002). "Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer". Cancer Res 62 (9): 2468–73. PMID 11980634. 
  3. ^ a b "Entrez Gene: PDGFD platelet derived growth factor D". 

Further reading[edit]