This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5q- syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
^Matsumoto T, Yokote K, Take A, Takemoto M, Asaumi S, Hashimoto Y et al. (April 2000). "Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation". Biochem. Biophys. Res. Commun.270 (1): 28–33. doi:10.1006/bbrc.2000.2374. PMID10733900.
^Yamamoto M, Toya Y, Jensen RA, Ishikawa Y (March 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor signaling". Exp. Cell Res.247 (2): 380–8. doi:10.1006/excr.1998.4379. PMID10066366.
^ abcBraverman LE, Quilliam LA (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". J. Biol. Chem.274 (9): 5542–9. PMID10026169.
^Tang J, Feng GS, Li W (October 1997). "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor". Oncogene15 (15): 1823–32. doi:10.1038/sj.onc.1201351. PMID9362449.
^Chen M, She H, Davis EM, Spicer CM, Kim L, Ren R et al. (September 1998). "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity". J. Biol. Chem.273 (39): 25171–8. PMID9737977.
^Rupp E, Siegbahn A, Rönnstrand L, Wernstedt C, Claesson-Welsh L, Heldin CH (October 1994). "A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex". Eur. J. Biochem.225 (1): 29–41. PMID7523122.
^Seifert RA, Hart CE, Phillips PE, Forstrom JW, Ross R, Murray MJ et al. (May 1989). "Two different subunits associate to create isoform-specific platelet-derived growth factor receptors". J. Biol. Chem.264 (15): 8771–8. PMID2542288.
^Lechleider RJ, Sugimoto S, Bennett AM, Kashishian AS, Cooper JA, Shoelson SE et al. (October 1993). "Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor". J. Biol. Chem.268 (29): 21478–81. PMID7691811.
^Farooqui T, Kelley T, Coggeshall KM, Rampersaud AA, Yates AJ. "GM1 inhibits early signaling events mediated by PDGF receptor in cultured human glioma cells". Anticancer Res.19 (6B): 5007–13. PMID10697503.
^Ekman S, Kallin A, Engström U, Heldin CH, Rönnstrand L (March 2002). "SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor". Oncogene21 (12): 1870–5. doi:10.1038/sj.onc.1205210. PMID11896619.
^Yokote K, Mori S, Hansen K, McGlade J, Pawson T, Heldin CH et al. (May 1994). "Direct interaction between Shc and the platelet-derived growth factor beta-receptor". J. Biol. Chem.269 (21): 15337–43. PMID8195171.