PDGFRB

Platelet-derived growth factor receptor, beta polypeptide
	; Ribbon image of two molecules of human PDGF receptor beta (yellow and magenta) in complex with dimeric PDGF-B (cyan and green).
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1H9O, 2L6W, 3MJG
Identifiers
Symbols	PDGFRB; CD140B; IBGC4; JTK12; PDGFR; PDGFR-1; PDGFR1
External IDs	OMIM: 173410 MGI: 97531 HomoloGene: 1960 ChEMBL: 1913 GeneCards: PDGFRB Gene
EC number	2.7.10.1
Gene Ontology
Molecular function	• protein tyrosine kinase activity; • platelet activating factor receptor activity; • platelet-derived growth factor-activated receptor activity; • platelet-derived growth factor beta-receptor activity; • vascular endothelial growth factor-activated receptor activity; • receptor binding; • platelet-derived growth factor receptor binding; • protein binding; • ATP binding; • vascular endothelial growth factor binding; • phosphatidylinositol 3-kinase binding; • platelet-derived growth factor binding;
Cellular component	• nucleus; • cytoplasm; • plasma membrane; • integral to plasma membrane; • membrane; • cytoplasmic membrane-bounded vesicle; • apical plasma membrane; • intrinsic to plasma membrane; • lysosomal lumen;
Biological process	• in utero embryonic development; • tissue homeostasis; • glycosaminoglycan biosynthetic process; • signal transduction; • epidermal growth factor receptor signaling pathway; • transforming growth factor beta receptor signaling pathway; • intracellular protein kinase cascade; • positive regulation of cell proliferation; • fibroblast growth factor receptor signaling pathway; • response to toxic substance; • positive regulation of phospholipase C activity; • positive regulation of phosphatidylinositol 3-kinase cascade; • positive regulation of smooth muscle cell migration; • cell migration; • peptidyl-tyrosine phosphorylation; • adrenal gland development; • positive regulation of cell migration; • response to estradiol stimulus; • positive regulation of phosphoprotein phosphatase activity; • response to retinoic acid; • regulation of actin cytoskeleton organization; • positive regulation of collagen biosynthetic process; • response to fluid shear stress; • cell migration involved in vasculogenesis; • metanephric mesenchymal cell migration; • platelet-derived growth factor receptor-beta signaling pathway; • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; • aorta morphogenesis; • cellular response to platelet-derived growth factor stimulus; • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; • wound healing; • response to hydrogen peroxide; • positive regulation of MAP kinase activity; • positive regulation of phosphatidylinositol 3-kinase activity; • innate immune response; • positive regulation of mitosis; • phosphatidylinositol metabolic process; • protein autophosphorylation; • platelet-derived growth factor receptor signaling pathway; • vascular endothelial growth factor receptor signaling pathway; • neurotrophin TRK receptor signaling pathway; • phosphatidylinositol-mediated signaling; • positive regulation of smooth muscle cell proliferation; • skeletal system morphogenesis; • smooth muscle tissue development; • inner ear development; • regulation of peptidyl-tyrosine phosphorylation; • positive regulation of chemotaxis; • cardiac myofibril assembly; • response to hyperoxia; • cell chemotaxis; • cell migration involved in coronary angiogenesis; • retina vasculature development in camera-type eye; • positive regulation of ERK1 and ERK2 cascade; • smooth muscle cell chemotaxis; • metanephric mesenchyme development; • metanephric glomerular mesangial cell proliferation involved in metanephros development; • metanephric glomerular capillary formation; • metanephric comma-shaped body morphogenesis; • metanephric S-shaped body morphogenesis; • positive regulation of calcium ion import; • positive regulation of reactive oxygen species metabolic process; • positive regulation of DNA biosynthetic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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Beta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene.

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.^[2]

Interactions [edit]

PDGFRB has been shown to interact with PTPN11,^[3]^[4] NCK1,^[5]^[6] Grb2,^[6]^[7]^[8] Caveolin 1,^[9] PDGFRA,^[10]^[11] Sodium-hydrogen antiporter 3 regulator 1,^[12] RAS p21 protein activator 1,^[13]^[14] CRK,^[15] SHC1^[16] and NCK2.^[6]^[17]^[18]

References [edit]

^ PDB 3MJG; Shima AHR, Liua H, Fociaa PJ, Chena X, Linb PC, He X. (2010). "Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex". PNAS 107 (25): 11307–12. doi:10.1073/pnas.1000806107. PMC 2895058. PMID 20534510. ; rendered using PyMOL.
^ "Entrez Gene: PDGFRB platelet-derived growth factor receptor, beta polypeptide".
^ Keilhack, H; Müller M, Böhmer S A, Frank C, Weidner K M, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Günther B, Müller T, Birchmeier C, Böhmer F D (January 2001). "Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the Sh2 Domain Protein Tyrosine Phosphatase Shp-1". J. Cell Biol. (United States) 152 (2): 325–34. doi:10.1083/jcb.152.2.325. ISSN 0021-9525. PMC 2199605. PMID 11266449.
^ Lechleider, R J; Sugimoto S, Bennett A M, Kashishian A S, Cooper J A, Shoelson S E, Walsh C T, Neel B G (October 1993). "Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor". J. Biol. Chem. (UNITED STATES) 268 (29): 21478–81. ISSN 0021-9258. PMID 7691811.
^ Li, W; Hu P, Skolnik E Y, Ullrich A, Schlessinger J (December 1992). "The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors". Mol. Cell. Biol. (UNITED STATES) 12 (12): 5824–33. doi:10.1128/MCB.12.12.5824. ISSN 0270-7306. PMC 360522. PMID 1333047.
^ ^a ^b ^c Braverman, L E; Quilliam L A (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". J. Biol. Chem. (UNITED STATES) 274 (9): 5542–9. doi:10.1074/jbc.274.9.5542. ISSN 0021-9258. PMID 10026169.
^ Arvidsson, A K; Rupp E, Nånberg E, Downward J, Rönnstrand L, Wennström S, Schlessinger J, Heldin C H, Claesson-Welsh L (October 1994). "Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation". Mol. Cell. Biol. (UNITED STATES) 14 (10): 6715–26. ISSN 0270-7306. PMC 359202. PMID 7935391.
^ Tang, J; Feng G S, Li W (October 1997). "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor". Oncogene (ENGLAND) 15 (15): 1823–32. doi:10.1038/sj.onc.1201351. ISSN 0950-9232. PMID 9362449.
^ Yamamoto, M; Toya Y, Jensen R A, Ishikawa Y (March 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor signaling". Exp. Cell Res. (UNITED STATES) 247 (2): 380–8. doi:10.1006/excr.1998.4379. ISSN 0014-4827. PMID 10066366.
^ Rupp, E; Siegbahn A, Rönnstrand L, Wernstedt C, Claesson-Welsh L, Heldin C H (October 1994). "A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex". Eur. J. Biochem. (GERMANY) 225 (1): 29–41. doi:10.1111/j.1432-1033.1994.00029.x. ISSN 0014-2956. PMID 7523122.
^ Seifert, R A; Hart C E, Phillips P E, Forstrom J W, Ross R, Murray M J, Bowen-Pope D F (May. 1989). "Two different subunits associate to create isoform-specific platelet-derived growth factor receptors". J. Biol. Chem. (UNITED STATES) 264 (15): 8771–8. ISSN 0021-9258. PMID 2542288.
^ Maudsley, S; Zamah A M, Rahman N, Blitzer J T, Luttrell L M, Lefkowitz R J, Hall R A (November 2000). "Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8352–63. doi:10.1128/MCB.20.22.8352-8363.2000. ISSN 0270-7306. PMC 102142. PMID 11046132.
^ Farooqui, T; Kelley T, Coggeshall K M, Rampersaud A A, Yates A J (1999). "GM1 inhibits early signaling events mediated by PDGF receptor in cultured human glioma cells". Anticancer Res. (GREECE) 19 (6B): 5007–13. ISSN 0250-7005. PMID 10697503.
^ Ekman, Simon; Kallin Anders, Engström Ulla, Heldin Carl-Henrik, Rönnstrand Lars (March 2002). "SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor". Oncogene (England) 21 (12): 1870–5. doi:10.1038/sj.onc.1205210. ISSN 0950-9232. PMID 11896619.
^ Matsumoto, T; Yokote K, Take A, Takemoto M, Asaumi S, Hashimoto Y, Matsuda M, Saito Y, Mori S (April 2000). "Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation". Biochem. Biophys. Res. Commun. (UNITED STATES) 270 (1): 28–33. doi:10.1006/bbrc.2000.2374. ISSN 0006-291X. PMID 10733900.
^ Yokote, K; Mori S, Hansen K, McGlade J, Pawson T, Heldin C H, Claesson-Welsh L (May. 1994). "Direct interaction between Shc and the platelet-derived growth factor beta-receptor". J. Biol. Chem. (UNITED STATES) 269 (21): 15337–43. ISSN 0021-9258. PMID 8195171.
^ Chen, M; She H, Davis E M, Spicer C M, Kim L, Ren R, Le Beau M M, Li W (September 1998). "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity". J. Biol. Chem. (UNITED STATES) 273 (39): 25171–8. doi:10.1074/jbc.273.39.25171. ISSN 0021-9258. PMID 9737977.
^ Chen, M; She H, Kim A, Woodley D T, Li W (November 2000). "Nckβ Adapter Regulates Actin Polymerization in NIH 3T3 Fibroblasts in Response to Platelet-Derived Growth Factor bb". Mol. Cell. Biol. (UNITED STATES) 20 (21): 7867–80. doi:10.1128/MCB.20.21.7867-7880.2000. ISSN 0270-7306. PMC 86398. PMID 11027258.

External links [edit]

CD140B Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

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[3MJG-1] PDB 3MJG; Shima AHR, Liua H, Fociaa PJ, Chena X, Linb PC, He X. (2010). "Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex". PNAS 107 (25): 11307–12. doi:10.1073/pnas.1000806107. PMC 2895058. PMID 20534510. ; rendered using PyMOL.

[2] "Entrez Gene: PDGFRB platelet-derived growth factor receptor, beta polypeptide".

[pmid11266449-3] Keilhack, H; Müller M, Böhmer S A, Frank C, Weidner K M, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Günther B, Müller T, Birchmeier C, Böhmer F D (January 2001). "Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the Sh2 Domain Protein Tyrosine Phosphatase Shp-1". J. Cell Biol. (United States) 152 (2): 325–34. doi:10.1083/jcb.152.2.325. ISSN 0021-9525. PMC 2199605. PMID 11266449.

[pmid7691811-4] Lechleider, R J; Sugimoto S, Bennett A M, Kashishian A S, Cooper J A, Shoelson S E, Walsh C T, Neel B G (October 1993). "Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor". J. Biol. Chem. (UNITED STATES) 268 (29): 21478–81. ISSN 0021-9258. PMID 7691811.

[pmid1333047-5] Li, W; Hu P, Skolnik E Y, Ullrich A, Schlessinger J (December 1992). "The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors". Mol. Cell. Biol. (UNITED STATES) 12 (12): 5824–33. doi:10.1128/MCB.12.12.5824. ISSN 0270-7306. PMC 360522. PMID 1333047.

[pmid10026169-6] Braverman, L E; Quilliam L A (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". J. Biol. Chem. (UNITED STATES) 274 (9): 5542–9. doi:10.1074/jbc.274.9.5542. ISSN 0021-9258. PMID 10026169.

[pmid7935391-7] Arvidsson, A K; Rupp E, Nånberg E, Downward J, Rönnstrand L, Wennström S, Schlessinger J, Heldin C H, Claesson-Welsh L (October 1994). "Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation". Mol. Cell. Biol. (UNITED STATES) 14 (10): 6715–26. ISSN 0270-7306. PMC 359202. PMID 7935391.

[pmid9362449-8] Tang, J; Feng G S, Li W (October 1997). "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor". Oncogene (ENGLAND) 15 (15): 1823–32. doi:10.1038/sj.onc.1201351. ISSN 0950-9232. PMID 9362449.

[pmid10066366-9] Yamamoto, M; Toya Y, Jensen R A, Ishikawa Y (March 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor signaling". Exp. Cell Res. (UNITED STATES) 247 (2): 380–8. doi:10.1006/excr.1998.4379. ISSN 0014-4827. PMID 10066366.

[pmid7523122-10] Rupp, E; Siegbahn A, Rönnstrand L, Wernstedt C, Claesson-Welsh L, Heldin C H (October 1994). "A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex". Eur. J. Biochem. (GERMANY) 225 (1): 29–41. doi:10.1111/j.1432-1033.1994.00029.x. ISSN 0014-2956. PMID 7523122.

[pmid2542288-11] Seifert, R A; Hart C E, Phillips P E, Forstrom J W, Ross R, Murray M J, Bowen-Pope D F (May. 1989). "Two different subunits associate to create isoform-specific platelet-derived growth factor receptors". J. Biol. Chem. (UNITED STATES) 264 (15): 8771–8. ISSN 0021-9258. PMID 2542288.

[pmid11046132-12] Maudsley, S; Zamah A M, Rahman N, Blitzer J T, Luttrell L M, Lefkowitz R J, Hall R A (November 2000). "Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8352–63. doi:10.1128/MCB.20.22.8352-8363.2000. ISSN 0270-7306. PMC 102142. PMID 11046132.

[pmid10697503-13] Farooqui, T; Kelley T, Coggeshall K M, Rampersaud A A, Yates A J (1999). "GM1 inhibits early signaling events mediated by PDGF receptor in cultured human glioma cells". Anticancer Res. (GREECE) 19 (6B): 5007–13. ISSN 0250-7005. PMID 10697503.

[pmid11896619-14] Ekman, Simon; Kallin Anders, Engström Ulla, Heldin Carl-Henrik, Rönnstrand Lars (March 2002). "SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor". Oncogene (England) 21 (12): 1870–5. doi:10.1038/sj.onc.1205210. ISSN 0950-9232. PMID 11896619.

[pmid10733900-15] Matsumoto, T; Yokote K, Take A, Takemoto M, Asaumi S, Hashimoto Y, Matsuda M, Saito Y, Mori S (April 2000). "Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation". Biochem. Biophys. Res. Commun. (UNITED STATES) 270 (1): 28–33. doi:10.1006/bbrc.2000.2374. ISSN 0006-291X. PMID 10733900.

[pmid8195171-16] Yokote, K; Mori S, Hansen K, McGlade J, Pawson T, Heldin C H, Claesson-Welsh L (May. 1994). "Direct interaction between Shc and the platelet-derived growth factor beta-receptor". J. Biol. Chem. (UNITED STATES) 269 (21): 15337–43. ISSN 0021-9258. PMID 8195171.

[pmid9737977-17] Chen, M; She H, Davis E M, Spicer C M, Kim L, Ren R, Le Beau M M, Li W (September 1998). "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity". J. Biol. Chem. (UNITED STATES) 273 (39): 25171–8. doi:10.1074/jbc.273.39.25171. ISSN 0021-9258. PMID 9737977.

[pmid11027258-18] Chen, M; She H, Kim A, Woodley D T, Li W (November 2000). "Nckβ Adapter Regulates Actin Polymerization in NIH 3T3 Fibroblasts in Response to Platelet-Derived Growth Factor bb". Mol. Cell. Biol. (UNITED STATES) 20 (21): 7867–80. doi:10.1128/MCB.20.21.7867-7880.2000. ISSN 0270-7306. PMC 86398. PMID 11027258.

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PDGFRB

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