PDGFRB

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Platelet-derived growth factor receptor, beta polypeptide
PDGFR-beta 3MJG.png
Ribbon image of two molecules of human PDGF receptor beta (yellow and magenta) in complex with dimeric PDGF-B (cyan and green).[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PDGFRB ; CD140B; IBGC4; JTK12; PDGFR; PDGFR-1; PDGFR1
External IDs OMIM173410 MGI97531 HomoloGene1960 ChEMBL: 1913 GeneCards: PDGFRB Gene
EC number 2.7.10.1
RNA expression pattern
PBB GE PDGFRB 202273 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5159 18596
Ensembl ENSG00000113721 ENSMUSG00000024620
UniProt P09619 P05622
RefSeq (mRNA) NM_002609 NM_001146268
RefSeq (protein) NP_002600 NP_001139740
Location (UCSC) Chr 5:
149.49 – 149.54 Mb
Chr 18:
61.05 – 61.09 Mb
PubMed search [1] [2]

Beta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene.

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5q- syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.[2]

Interactions[edit]

PDGFRB has been shown to interact with PTPN11,[3][4] NCK1,[5][6] Grb2,[6][7][8] Caveolin 1,[9] PDGFRA,[10][11] Sodium-hydrogen antiporter 3 regulator 1,[12] RAS p21 protein activator 1,[13][14] CRK,[15] SHC1[16] and NCK2.[6][17][18]

See also[edit]

References[edit]

  1. ^ PDB 3MJG; Shima AHR, Liua H, Fociaa PJ, Chena X, Linb PC, He X. (2010). "Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex". PNAS 107 (25): 11307–12. doi:10.1073/pnas.1000806107. PMC 2895058. PMID 20534510. ; rendered using PyMOL.
  2. ^ "Entrez Gene: PDGFRB platelet-derived growth factor receptor, beta polypeptide". 
  3. ^ Keilhack, H; Müller M, Böhmer S A, Frank C, Weidner K M, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Günther B, Müller T, Birchmeier C, Böhmer F D (January 2001). "Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the Sh2 Domain Protein Tyrosine Phosphatase Shp-1". J. Cell Biol. (United States) 152 (2): 325–34. doi:10.1083/jcb.152.2.325. ISSN 0021-9525. PMC 2199605. PMID 11266449. 
  4. ^ Lechleider, R J; Sugimoto S; Bennett A M; Kashishian A S; Cooper J A; Shoelson S E; Walsh C T; Neel B G (October 1993). "Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor". J. Biol. Chem. (UNITED STATES) 268 (29): 21478–81. ISSN 0021-9258. PMID 7691811. 
  5. ^ Li, W; Hu P; Skolnik E Y; Ullrich A; Schlessinger J (December 1992). "The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors". Mol. Cell. Biol. (UNITED STATES) 12 (12): 5824–33. doi:10.1128/MCB.12.12.5824. ISSN 0270-7306. PMC 360522. PMID 1333047. 
  6. ^ a b c Braverman, L E; Quilliam L A (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". J. Biol. Chem. (UNITED STATES) 274 (9): 5542–9. doi:10.1074/jbc.274.9.5542. ISSN 0021-9258. PMID 10026169. 
  7. ^ Arvidsson, A K; Rupp E; Nånberg E; Downward J; Rönnstrand L; Wennström S; Schlessinger J; Heldin C H; Claesson-Welsh L (October 1994). "Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation". Mol. Cell. Biol. (UNITED STATES) 14 (10): 6715–26. ISSN 0270-7306. PMC 359202. PMID 7935391. 
  8. ^ Tang, J; Feng G S; Li W (October 1997). "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor". Oncogene (ENGLAND) 15 (15): 1823–32. doi:10.1038/sj.onc.1201351. ISSN 0950-9232. PMID 9362449. 
  9. ^ Yamamoto, M; Toya Y; Jensen R A; Ishikawa Y (March 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor signaling". Exp. Cell Res. (UNITED STATES) 247 (2): 380–8. doi:10.1006/excr.1998.4379. ISSN 0014-4827. PMID 10066366. 
  10. ^ Rupp, E; Siegbahn A; Rönnstrand L; Wernstedt C; Claesson-Welsh L; Heldin C H (October 1994). "A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex". Eur. J. Biochem. (GERMANY) 225 (1): 29–41. doi:10.1111/j.1432-1033.1994.00029.x. ISSN 0014-2956. PMID 7523122. 
  11. ^ Seifert, R A; Hart C E; Phillips P E; Forstrom J W; Ross R; Murray M J; Bowen-Pope D F (May 1989). "Two different subunits associate to create isoform-specific platelet-derived growth factor receptors". J. Biol. Chem. (UNITED STATES) 264 (15): 8771–8. ISSN 0021-9258. PMID 2542288. 
  12. ^ Maudsley, S; Zamah A M; Rahman N; Blitzer J T; Luttrell L M; Lefkowitz R J; Hall R A (November 2000). "Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8352–63. doi:10.1128/MCB.20.22.8352-8363.2000. ISSN 0270-7306. PMC 102142. PMID 11046132. 
  13. ^ Farooqui, T; Kelley T; Coggeshall K M; Rampersaud A A; Yates A J (1999). "GM1 inhibits early signaling events mediated by PDGF receptor in cultured human glioma cells". Anticancer Res. (GREECE) 19 (6B): 5007–13. ISSN 0250-7005. PMID 10697503. 
  14. ^ Ekman, Simon; Kallin Anders; Engström Ulla; Heldin Carl-Henrik; Rönnstrand Lars (March 2002). "SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor". Oncogene (England) 21 (12): 1870–5. doi:10.1038/sj.onc.1205210. ISSN 0950-9232. PMID 11896619. 
  15. ^ Matsumoto, T; Yokote K; Take A; Takemoto M; Asaumi S; Hashimoto Y; Matsuda M; Saito Y; Mori S (April 2000). "Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation". Biochem. Biophys. Res. Commun. (UNITED STATES) 270 (1): 28–33. doi:10.1006/bbrc.2000.2374. ISSN 0006-291X. PMID 10733900. 
  16. ^ Yokote, K; Mori S; Hansen K; McGlade J; Pawson T; Heldin C H; Claesson-Welsh L (May 1994). "Direct interaction between Shc and the platelet-derived growth factor beta-receptor". J. Biol. Chem. (UNITED STATES) 269 (21): 15337–43. ISSN 0021-9258. PMID 8195171. 
  17. ^ Chen, M; She H; Davis E M; Spicer C M; Kim L; Ren R; Le Beau M M; Li W (September 1998). "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity". J. Biol. Chem. (UNITED STATES) 273 (39): 25171–8. doi:10.1074/jbc.273.39.25171. ISSN 0021-9258. PMID 9737977. 
  18. ^ Chen, M; She H; Kim A; Woodley D T; Li W (November 2000). "Nckβ Adapter Regulates Actin Polymerization in NIH 3T3 Fibroblasts in Response to Platelet-Derived Growth Factor bb". Mol. Cell. Biol. (UNITED STATES) 20 (21): 7867–80. doi:10.1128/MCB.20.21.7867-7880.2000. ISSN 0270-7306. PMC 86398. PMID 11027258. 

Further reading[edit]

  • Hart CE, Bowen-Pope DF (1990). "Platelet-derived growth factor receptor: current views of the two-subunit model". J. Invest. Dermatol. 94 (6 Suppl): 53S–57S. doi:10.1111/1523-1747.ep12875065. PMID 2161888. 
  • Steer EJ, Cross NC (2002). "Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor Beta". Acta Haematol. 107 (2): 113–22. doi:10.1159/000046641. PMID 11919393. 

External links[edit]