Pyruvate dehydrogenase (lipoamide) alpha 1

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Pyruvate dehydrogenase (lipoamide) alpha 1
Protein PDHA1 PDB 1ni4.png
PDB rendering based on 1ni4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PDHA1 ; PDHA; PDHCE1A; PHE1A
External IDs OMIM300502 MGI97532 HomoloGene121491 ChEMBL: 2092 GeneCards: PDHA1 Gene
EC number 1.2.4.1
RNA expression pattern
PBB GE PDHA1 200980 s at tn.png
PBB GE PDHA1 200979 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5160 18597
Ensembl ENSG00000131828 ENSMUSG00000031299
UniProt P08559 P35486
RefSeq (mRNA) NM_000284 NM_008810
RefSeq (protein) NP_000275 NP_032836
Location (UCSC) Chr X:
19.36 – 19.38 Mb
Chr X:
160.12 – 160.14 Mb
PubMed search [1] [2]

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial is an enzyme that in humans is encoded by the PDHA1 gene.

The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1); dihydrolipoyl transacetylase (DLAT; MIM 608770) (E2; EC 2.3.1.12); and dihydrolipoyl dehydrogenase (DLD; MIM 238331) (E3; EC 1.8.1.4). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex (Brown et al., 1994).[supplied by OMIM][1]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
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Glycolysis and Gluconeogenesis edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534". 

References[edit]

Further reading[edit]