Pyruvate dehydrogenase lipoamide kinase isozyme 1

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Not to be confused with the master kinase PDK1, 3-phosphoinositide-dependent protein kinase (PDPK1).
Pyruvate dehydrogenase kinase, isozyme 1
Protein PDK1 PDB 2Q8F.png
Rendering based on PDB 2Q8F.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol PDK1
External IDs OMIM602524 MGI1926119 HomoloGene134437 ChEMBL: 4766 GeneCards: PDK1 Gene
EC number
RNA expression pattern
PBB GE PDK1 206686 at tn.png
More reference expression data
Species Human Mouse
Entrez 5163 228026
Ensembl ENSG00000152256 ENSMUSG00000006494
UniProt Q15118 Q8BFP9
RefSeq (mRNA) NM_001278549 NM_172665
RefSeq (protein) NP_001265478 NP_766253
Location (UCSC) Chr 2:
173.42 – 173.49 Mb
Chr 2:
71.87 – 71.9 Mb
PubMed search [1] [2]

Pyruvate dehydrogenase lipoamide kinase isozyme 1, mitochondrial is an enzyme that in humans is encoded by the PDK1 gene.[1][2] It codes for an isozyme of pyruvate dehydrogenase kinase (PDK).

Pyruvate dehydrogenase (PDH) is a part of a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.[2]


  1. ^ Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (Jan 1996). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". J Biol Chem 270 (48): 28989–94. doi:10.1074/jbc.270.48.28989. PMID 7499431. 
  2. ^ a b "Entrez Gene: PDK1 pyruvate dehydrogenase kinase, isozyme 1". 

Further reading[edit]