PDLIM1

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PDZ and LIM domain 1
Protein PDLIM1 PDB 1x62.png
PDB rendering based on 1x62.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PDLIM1 ; CLIM1; CLP-36; CLP36; HEL-S-112; hCLIM1
External IDs OMIM605900 MGI1860611 HomoloGene9643 GeneCards: PDLIM1 Gene
RNA expression pattern
PBB GE PDLIM1 208690 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9124 54132
Ensembl ENSG00000107438 ENSMUSG00000055044
UniProt O00151 O70400
RefSeq (mRNA) NM_020992 NM_016861
RefSeq (protein) NP_066272 NP_058557
Location (UCSC) Chr 10:
97 – 97.05 Mb
Chr 19:
40.22 – 40.27 Mb
PubMed search [1] [2]

PDZ and LIM domain protein 1 is a protein that in humans is encoded by the PDLIM1 gene.[1][2]


Interactions[edit]

PDLIM1 has been shown to interact with Estrogen receptor alpha,[3] Actinin alpha 4,[4][5] Actinin, alpha 1[5][6] and RNF12.[3]

References[edit]

  1. ^ Kotaka M, Kostin S, Ngai S, Chan K, Lau Y, Lee SM, Li H, Ng EK, Schaper J, Tsui SK, Fung K, Lee C, Waye MM (October 2000). "Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2". J Cell Biochem 78 (4): 558–65. doi:10.1002/1097-4644(20000915)78:4<558::AID-JCB5>3.0.CO;2-I. PMID 10861853. 
  2. ^ "Entrez Gene: PDLIM1 PDZ and LIM domain 1 (elfin)". 
  3. ^ a b Johnsen, Steven A; Güngör Cenap, Prenzel Tanja, Riethdorf Sabine, Riethdorf Lutz, Taniguchi-Ishigaki Naoko, Rau Thomas, Tursun Baris, Furlow J David, Sauter Guido, Scheffner Martin, Pantel Klaus, Gannon Frank, Bach Ingolf (January 2009). "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer". Cancer Res. (United States) 69 (1): 128–36. doi:10.1158/0008-5472.CAN-08-1630. PMC 2713826. PMID 19117995. 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ a b Vallenius, T; Luukko K; Mäkelä T P (April 2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4". J. Biol. Chem. (UNITED STATES) 275 (15): 11100–5. doi:10.1074/jbc.275.15.11100. ISSN 0021-9258. PMID 10753915. 
  6. ^ Bauer, K; Kratzer M; Otte M; de Quintana K L; Hagmann J; Arnold G J; Eckerskorn C; Lottspeich F; Siess W (December 2000). "Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells". Blood (UNITED STATES) 96 (13): 4236–45. ISSN 0006-4971. PMID 11110697. 

Further reading[edit]