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PDZ and LIM domain 5
Protein PDLIM5 PDB 1wf7.png
PDB rendering based on 1wf7.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PDLIM5 ; ENH; ENH1; LIM
External IDs OMIM605904 MGI1927489 HomoloGene21289 GeneCards: PDLIM5 Gene
RNA expression pattern
PBB GE PDLIM5 203243 s at tn.png
PBB GE PDLIM5 203242 s at tn.png
PBB GE PDLIM5 211681 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10611 56376
Ensembl ENSG00000163110 ENSMUSG00000028273
UniProt Q96HC4 Q8CI51
RefSeq (mRNA) NM_001011513 NM_001190852
RefSeq (protein) NP_001011513 NP_001177781
Location (UCSC) Chr 4:
95.37 – 95.59 Mb
Chr 3:
142.24 – 142.4 Mb
PubMed search [1] [2]

PDZ and LIM domain protein 5 is a protein that in humans is encoded by the PDLIM5 gene.[1][2]

The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized.[2]


PDLIM5 has been shown to interact with PRKCB1.[3]


  1. ^ Wu M, Li Y, Ji C, Xu J, Zheng H, Zou X, Gu S, Lou Y, Xie Y, Mao Y (September 2004). "Cloning and identification of a novel human gene PDLIM5, a homolog of AD-associated neuronal thread protein (AD7c-NTP)". DNA Seq 15 (2): 144–7. doi:10.1080/10425170310001656756. PMID 15346770. 
  2. ^ a b "Entrez Gene: PDLIM5 PDZ and LIM domain 5". 
  3. ^ Kuroda, S; Tokunaga C; Kiyohara Y; Higuchi O; Konishi H; Mizuno K; Gill G N; Kikkawa U (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. (UNITED STATES) 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. ISSN 0021-9258. PMID 8940095. 

Further reading[edit]