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PDZ and LIM domain 7 (enigma)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PDLIM7 ; LMP1; LMP3
External IDs OMIM605903 HomoloGene3980 GeneCards: PDLIM7 Gene
RNA expression pattern
PBB GE PDLIM7 203370 s at tn.png
PBB GE PDLIM7 203369 x at tn.png
PBB GE PDLIM7 214266 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9260 67399
Ensembl ENSG00000196923 ENSMUSG00000021493
UniProt Q9NR12 Q3TJD7
RefSeq (mRNA) NM_005451 NM_001114087
RefSeq (protein) NP_005442 NP_001107559
Location (UCSC) Chr 5:
176.91 – 176.92 Mb
Chr 13:
55.5 – 55.51 Mb
PubMed search [1] [2]

PDZ and LIM domain protein 7 is a protein that in humans is encoded by the PDLIM7 gene.[1][2]

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein–protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.[2]


PDLIM7 has been shown to interact with TPM2.[3]


  1. ^ Liu Y, Hair GA, Boden SD, Viggeswarapu M, Titus L (Mar 2002). "Overexpressed LIM mineralization proteins do not require LIM domains to induce bone". J Bone Miner Res 17 (3): 406–14. doi:10.1359/jbmr.2002.17.3.406. PMID 11874232. 
  2. ^ a b "Entrez Gene: PDLIM7 PDZ and LIM domain 7 (enigma)". 
  3. ^ Guy, P M; Kenny D A; Gill G N (Jun 1999). "The PDZ domain of the LIM protein enigma binds to beta-tropomyosin". Mol. Biol. Cell (UNITED STATES) 10 (6): 1973–84. doi:10.1091/mbc.10.6.1973. ISSN 1059-1524. PMC 25398. PMID 10359609. 

Further reading[edit]