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PDZ domain containing 1
Protein PDZK1 PDB 2EEI.png
Rendering based on PDB 2EEI.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603831 MGI1928901 HomoloGene1964 GeneCards: PDZK1 Gene
Species Human Mouse
Entrez 5174 59020
Ensembl ENSG00000174827 ENSMUSG00000038298
UniProt Q5T2W1 Q9JIL4
RefSeq (mRNA) NM_001201325 NM_001146001
RefSeq (protein) NP_001188254 NP_001139473
Location (UCSC) Chr 1:
145.73 – 145.76 Mb
Chr 3:
96.83 – 96.87 Mb
PubMed search [1] [2]

Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene.[1][2]


PDZK1 has been shown to interact with:

Related gene problems[edit]


  1. ^ Kocher O, Comella N, Tognazzi K, Brown LF (March 1998). "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains". Lab Invest 78 (1): 117–25. PMID 9461128. 
  2. ^ "Entrez Gene: PDZK1 PDZ domain containing 1". 
  3. ^ a b c d e f g h Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA et al. (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806. 
  4. ^ a b Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR (February 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. 278 (8): 6440–9. doi:10.1074/jbc.M211050200. PMID 12471024. 
  5. ^ Wang S, Yue H, Derin RB, Guggino WB, Li M (September 2000). "Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity". Cell 103 (1): 169–79. doi:10.1016/s0092-8674(00)00096-9. PMID 11051556. 
  6. ^ Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V et al. (October 2003). "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol. 285 (4): F784–91. doi:10.1152/ajprenal.00109.2003. PMID 12837682. 
  7. ^ Silver DL, Wang N, Vogel S (August 2003). "Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels". J. Biol. Chem. 278 (31): 28528–32. doi:10.1074/jbc.M304109200. PMID 12754212. 
  8. ^ Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129. 

Further reading[edit]