PD 144418

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PD 144418
PD144418.png
Systematic (IUPAC) name
1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine
Clinical data
Legal status
?
Identifiers
CAS number 154130-99-1
ATC code ?
ChemSpider 7992981
Chemical data
Formula C18H22N2O 
Mol. mass 282.38 g/mol

PD 144418 or 1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine is a potent and selective ligand for the sigma-1 receptor, with a reported binding affinity of Ki = 0.08 ± 0.01 nM, and 17 212 times selectivity over the sigma-2 receptor.[1]

References[edit]

  1. ^ Akunne HC, Whetzel SZ, Wiley JN, Corbin AE, Ninteman FW, Tecle H, Pei Y, Pugsley TA, Heffner TG (January 1997). "The pharmacology of the novel and selective sigma ligand, PD 144418". Neuropharmacology 36 (1): 51–62. doi:10.1016/S0028-3908(96)00161-X. PMID 9144641.