PEG 400

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Polyethylene glycol
Polyethylene glycol
Identifiers
CAS number 25322-68-3 YesY
Properties
Molecular formula C2nH4n+2On+1, n = 8.2 to 9.1
Molar mass 380-420 g/mol
Density 1.128 g/cm³
Melting point 4-8°C
Viscosity 90.0 cSt at 25 °C, 7.3 cSt at 99 °C
Hazards
Flash point 238 °C (460 °F; 511 K)
LD50 30 mL/kg, orally in rats
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

PEG 400 (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. It is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations. More recently, it has been used to make e-liquid for electronic cigarettes[citation needed].

Chemical properties[edit]

PEG 400 is strongly hydrophilic. The partition coefficient of PEG 400 between hexane and water is 0.000015 (logP = -4.8), indicating that when PEG 400 is mixed with water and hexane, there are only 15 parts of PEG 400 in the hexane layer per 1 million parts of PEG 400 in the water layer.[1]

PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons.

References[edit]

  1. ^ T. Y. Ma, D. Hollander, P. Krugliak, K. Katz (1990). "PEG 400, a hydrophilic molecular probe for measuring intestinal permeability". Gastroenterology 98 (1): 39–46. PMID 2293598. 
  • The Merck Index, 11th Edition
  • Handbook of Pharmaceutical Excipients