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Pescadillo ribosomal biogenesis factor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PES1 ; PES
External IDs OMIM605819 MGI1890613 HomoloGene5984 GeneCards: PES1 Gene
RNA expression pattern
PBB GE PES1 202212 at tn.png
More reference expression data
Species Human Mouse
Entrez 23481 64934
Ensembl ENSG00000100029 ENSMUSG00000020430
UniProt O00541 Q9EQ61
RefSeq (mRNA) NM_001243225 NM_022889
RefSeq (protein) NP_001230154 NP_075027
Location (UCSC) Chr 22:
30.97 – 31 Mb
Chr 11:
3.96 – 3.98 Mb
PubMed search [1] [2]

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.[1][2][3][4]

This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.[4]


  1. ^ Allende ML, Amsterdam A, Becker T, Kawakami K, Gaiano N, Hopkins N (Jan 1997). "Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development". Genes Dev 10 (24): 3141–55. doi:10.1101/gad.10.24.3141. PMID 8985183. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ Rohrmoser M, Holzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D (May 2007). "Interdependence of Pes1, Bop1, and WDR12 Controls Nucleolar Localization and Assembly of the PeBoW Complex Required for Maturation of the 60S Ribosomal Subunit". Mol Cell Biol 27 (10): 3682–94. doi:10.1128/MCB.00172-07. PMC 1899993. PMID 17353269. 
  4. ^ a b "Entrez Gene: PES1 pescadillo homolog 1, containing BRCT domain (zebrafish)". 

Further reading[edit]