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Peroxisomal biogenesis factor 14
Protein PEX14 PDB 2W84.png
Rendering based on PDB 2W84.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PEX14 ; NAPP2; PBD13A; Pex14p; dJ734G22.2
External IDs OMIM601791 MGI1927868 HomoloGene37936 GeneCards: PEX14 Gene
RNA expression pattern
PBB GE PEX14 33760 at tn.png
PBB GE PEX14 203503 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5195 56273
Ensembl ENSG00000142655 ENSMUSG00000028975
UniProt O75381 Q9R0A0
RefSeq (mRNA) NM_004565 NM_019781
RefSeq (protein) NP_004556 NP_062755
Location (UCSC) Chr 1:
10.53 – 10.69 Mb
Chr 4:
148.96 – 149.1 Mb
PubMed search [1] [2]

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.[1][2]

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.[2]


PEX14 has been shown to interact with


  1. ^ Fransen M, Terlecky SR, Subramani S (Aug 1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proc Natl Acad Sci U S A 95 (14): 8087–92. doi:10.1073/pnas.95.14.8087. PMC 20933. PMID 9653144. 
  2. ^ a b "Entrez Gene: PEX14 peroxisomal biogenesis factor 14". 
  3. ^ a b Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002). "Peroxisomal Targeting Signal Receptor Pex5p Interacts with Cargoes and Import Machinery Components in a Spatiotemporally Differentiated Manner: Conserved Pex5p WXXXF/Y Motifs Are Critical for Matrix Protein Import". Mol. Cell. Biol. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044. 
  4. ^ Okumoto K, Abe I, Fujiki Y (August 2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p". J. Biol. Chem. 275 (33): 25700–10. doi:10.1074/jbc.M003303200. PMID 10837480. 
  5. ^ Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y (April 1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". J. Biol. Chem. 274 (18): 12593–604. doi:10.1074/jbc.274.18.12593. PMID 10212238. 
  6. ^ a b Managadze D, Würtz C, Sichting M, Niehaus G, Veenhuis M, Rottensteiner H (June 2007). "The peroxin PEX14 of Neurospora crassa is essential for the biogenesis of both glyoxysomes and Woronin bodies". Traffic 8 (6): 687–701. doi:10.1111/j.1600-0854.2007.00560.x. PMID 17461798. 

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