PEX16

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Peroxisomal biogenesis factor 16
Identifiers
Symbols PEX16 ; PBD8A; PBD8B
External IDs OMIM603360 MGI1338829 HomoloGene3537 GeneCards: PEX16 Gene
RNA expression pattern
PBB GE PEX16 221603 at tn.png
PBB GE PEX16 221604 s at tn.png
PBB GE PEX16 49878 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9409 18633
Ensembl ENSG00000121680 ENSMUSG00000027222
UniProt Q9Y5Y5 Q91XC9
RefSeq (mRNA) NM_004813 NM_145122
RefSeq (protein) NP_004804 NP_660104
Location (UCSC) Chr 11:
45.93 – 45.94 Mb
Chr 2:
92.37 – 92.38 Mb
PubMed search [1] [2]

Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.[1][2]

Function[edit]

The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described.[2]

Interactions[edit]

PEX16 has been shown to interact with PEX19.[3]

References[edit]

  1. ^ South ST, Gould SJ (Mar 1999). "Peroxisome Synthesis in the Absence of Preexisting Peroxisomes". J Cell Biol 144 (2): 255–66. doi:10.1083/jcb.144.2.255. PMC 2132891. PMID 9922452. 
  2. ^ a b "Entrez Gene: PEX16 peroxisomal biogenesis factor 16". 
  3. ^ Fransen, M; Wylin T, Brees C, Mannaerts G P, Van Veldhoven P P (Jul 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. (United States) 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669. 

Further reading[edit]

External links[edit]