PEX19

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Peroxisomal biogenesis factor 19
Protein PEX19 PDB 2W85.png
Rendering based on PDB 2W85.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PEX19 ; D1S2223E; HK33; PBD12A; PMP1; PMPI; PXF; PXMP1
External IDs OMIM600279 MGI1334458 HomoloGene37696 GeneCards: PEX19 Gene
RNA expression pattern
PBB GE PEX19 201707 at tn.png
PBB GE PEX19 201706 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5824 19298
Ensembl ENSG00000162735 ENSMUSG00000003464
UniProt P40855 Q8VCI5
RefSeq (mRNA) NM_001131039 NM_001159525
RefSeq (protein) NP_001180573 NP_001152997
Location (UCSC) Chr 1:
160.25 – 160.26 Mb
Chr 1:
172.13 – 172.14 Mb
PubMed search [1] [2]

Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene.[1][2][3]

Interactions[edit]

PEX19 has been shown to interact with PEX10,[4][5] PEX12,[4][5] PEX13,[4][5] ABCD3,[4][6][7][8] ABCD1,[6][7] PEX3,[4][5][6][9] ABCD2,[6][7] PEX11B[4][5] and PEX16.[5]

References[edit]

  1. ^ Kammerer S, Arnold N, Gutensohn W, Mewes HW, Kunau WH, Hofler G, Roscher AA, Braun A (November 1997). "Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein". Genomics 45 (1): 200–10. doi:10.1006/geno.1997.4914. PMID 9339377. 
  2. ^ Matsuzono Y, Kinoshita N, Tamura S, Shimozawa N, Hamasaki M, Ghaedi K, Wanders RJ, Suzuki Y, Kondo N, Fujiki Y (April 1999). "Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly". Proc Natl Acad Sci U S A 96 (5): 2116–21. doi:10.1073/pnas.96.5.2116. PMC 26746. PMID 10051604. 
  3. ^ "Entrez Gene: PEX19 peroxisomal biogenesis factor 19". 
  4. ^ a b c d e f Sacksteder, K A; Jones J M, South S T, Li X, Liu Y, Gould S J (March 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. (UNITED STATES) 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN 0021-9525. PMC 2174547. PMID 10704444. 
  5. ^ a b c d e f Fransen, M; Wylin T, Brees C, Mannaerts G P, Van Veldhoven P P (July 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. (United States) 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669. 
  6. ^ a b c d Mayerhofer, Peter U; Kattenfeld Tanja, Roscher Adelbert A, Muntau Ania C (March 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. (United States) 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. ISSN 0006-291X. PMID 11883941. 
  7. ^ a b c Gloeckner, C J; Mayerhofer P U, Landgraf P, Muntau A C, Holzinger A, Gerber J K, Kammerer S, Adamski J, Roscher A A (April 2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p". Biochem. Biophys. Res. Commun. (UNITED STATES) 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. ISSN 0006-291X. PMID 10777694. 
  8. ^ Biermanns, M; Gärtner J (July 2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes". Biochem. Biophys. Res. Commun. (United States) 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. ISSN 0006-291X. PMID 11453642. 
  9. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]

External links[edit]