PEX6

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Peroxisomal biogenesis factor 6
Identifiers
Symbols PEX6 ; PAF-2; PAF2; PBD4A; PDB4B; PXAAA1
External IDs OMIM601498 MGI2385054 HomoloGene47914 GeneCards: PEX6 Gene
RNA expression pattern
PBB GE PEX6 320 at tn.png
PBB GE PEX6 204545 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5190 224824
Ensembl ENSG00000124587 ENSMUSG00000002763
UniProt Q13608 Q99LC9
RefSeq (mRNA) NM_000287 NM_145488
RefSeq (protein) NP_000278 NP_663463
Location (UCSC) Chr 6:
42.93 – 42.95 Mb
Chr 17:
46.71 – 46.73 Mb
PubMed search [1] [2]

Peroxisome assembly factor 2 is a protein that in humans is encoded by the PEX6 gene.[1][2]

Interactions[edit]

PEX6 has been shown to interact with PEX1[3][4] and PEX26.[5]

References[edit]

  1. ^ Yahraus T, Braverman N, Dodt G, Kalish JE, Morrell JC, Moser HW, Valle D, Gould SJ (Aug 1996). "The peroxisome biogenesis disorder group 4 gene, PXAAA1, encodes a cytoplasmic ATPase required for stability of the PTS1 receptor". EMBO J 15 (12): 2914–23. PMC 450231. PMID 8670792. 
  2. ^ "Entrez Gene: PEX6 peroxisomal biogenesis factor 6". 
  3. ^ Tamura, S; Shimozawa N, Suzuki Y, Tsukamoto T, Osumi T, Fujiki Y (Apr 1998). "A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p". Biochem. Biophys. Res. Commun. (UNITED STATES) 245 (3): 883–6. doi:10.1006/bbrc.1998.8522. ISSN 0006-291X. PMID 9588209. 
  4. ^ Geisbrecht, B V; Collins C S, Reuber B E, Gould S J (Jul 1998). "Disruption of a PEX1-PEX6 interaction is the most common cause of the neurologic disorders Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (15): 8630–5. doi:10.1073/pnas.95.15.8630. ISSN 0027-8424. PMC 21127. PMID 9671729. 
  5. ^ Matsumoto, Naomi; Tamura Shigehiko, Fujiki Yukio (May 2003). "The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes". Nat. Cell Biol. (England) 5 (5): 454–60. doi:10.1038/ncb982. ISSN 1465-7392. PMID 12717447. 

Further reading[edit]

External links[edit]