PF-05089771

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PF-05089771 is a selective, small-molecule Nav1.7 and Nav1.8 voltage-gated sodium channel blocker under development by Pfizer as a novel analgesic.[1][2] As of June 2014, it has completed phase II clinical trials for wisdom tooth removal and primary erythromelalgia.[3]

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  1. ^ McMahon, Stephen; Koltzenburg, Martin; Tracey, Irene; Turk, Dennis C. (1 March 2013). Wall & Melzack's Textbook of Pain: Expert Consult - Online. Elsevier Health Sciences. p. 508. ISBN 0-7020-5374-0. 
  2. ^ Martz, Lauren (2014). "Nav-i-gating antibodies for pain". Science-Business eXchange 7 (23). doi:10.1038/scibx.2014.662. ISSN 1945-3477. 
  3. ^ Bagal, Sharan K.; Chapman, Mark L.; Marron, Brian E.; Prime, Rebecca; Ian Storer, R.; Swain, Nigel A. (2014). "Recent progress in sodium channel modulators for pain". Bioorganic & Medicinal Chemistry Letters. doi:10.1016/j.bmcl.2014.06.038. ISSN 0960-894X.