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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Symbols PFKFB2 ; PFK-2/FBPase-2
External IDs OMIM171835 MGI107815 HomoloGene88554 GeneCards: PFKFB2 Gene
EC number,
RNA expression pattern
PBB GE PFKFB2 209992 at tn.png
PBB GE PFKFB2 207931 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5208 18640
Ensembl ENSG00000123836 ENSMUSG00000026409
UniProt O60825 P70265
RefSeq (mRNA) NM_001018053 NM_001162415
RefSeq (protein) NP_001018063 NP_001155887
Location (UCSC) Chr 1:
207.22 – 207.25 Mb
Chr 1:
130.69 – 130.73 Mb
PubMed search [1] [2]

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene.[1]

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.[1]


PFKFB2 has been shown to interact with YWHAQ.[2]


  1. ^ a b "Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2". 
  2. ^ Pozuelo Rubio, Mercedes; Peggie Mark, Wong Barry H C, Morrice Nick, MacKintosh Carol (Jul 2003). "14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase". EMBO J. (England) 22 (14): 3514–23. doi:10.1093/emboj/cdg363. ISSN 0261-4189. PMC 165633. PMID 12853467. 

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