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Pepsinogen 5, group I (pepsinogen A)
Protein PGA5 PDB 1flh.png
PDB rendering based on 1flh.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PGA5 ; PGA3; PGA4
External IDs OMIM169730 HomoloGene68135 IUPHAR: 2390 ChEMBL: 3447 GeneCards: PGA5 Gene
EC number
RNA expression pattern
PBB GE PGA5 213265 at tn.png
More reference expression data
Species Human Mouse
Entrez 5222 n/a
Ensembl ENSG00000229183 n/a
UniProt P0DJD9 n/a
RefSeq (mRNA) NM_014224 n/a
RefSeq (protein) NP_055039 n/a
Location (UCSC) Chr 11:
61.01 – 61.02 Mb
PubMed search [1] n/a

Pepsin A is a protein that in humans is encoded by the PGA5 gene.[1]


Further reading[edit]

  • Ichinose M, Miki K, Wong RN et al. (1991). "Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer.". Jpn. J. Cancer Res. 82 (6): 686–92. doi:10.1111/j.1349-7006.1991.tb01904.x. PMID 1906854. 
  • Ichihara Y, Sogawa K, Takahashi K (1986). "Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.". J. Biochem. 98 (2): 483–92. PMID 2415509. 
  • Athauda SB, Tanji M, Kageyama T, Takahashi K (1990). "A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.". J. Biochem. 106 (5): 920–7. PMID 2515193. 
  • Hengels KJ, Strohmeyer G (1990). "Pepsinogens A and C: purification from human gastric mucosa and determination in serum by optimized radioimmunoassays.". Zeitschrift für Gastroenterologie 27 (8): 406–11. PMID 2609705. 
  • Evers MP, Zelle B, Bebelman JP et al. (1989). "Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.". Genomics 4 (3): 232–9. doi:10.1016/0888-7543(89)90325-X. PMID 2714789. 
  • ten Kate RW, Pals G, Donker AJ et al. (1989). "Tubular handling of pepsinogen A and C in man: evidence for two distinct tubular reabsorption mechanisms for low molecular weight proteins in man.". Nephron 53 (3): 223–8. doi:10.1159/000185748. PMID 2797342. 
  • ten Kate RW, Pals G, Eriksson AW et al. (1989). "The renal metabolism of pepsinogen A and C in man.". Clin. Nephrol. 31 (2): 103–6. PMID 2920466. 
  • Evers MP, Zelle B, Peeper DS et al. (1987). "Molecular cloning of a pair of human pepsinogen A genes which differ by a Glu----Lys mutation in the activation peptide.". Hum. Genet. 77 (2): 182–7. doi:10.1007/BF00272389. PMID 3115885. 
  • Pals G, Eriksson AW, Pronk JC et al. (1989). "Differential expression of pepsinogen isozymogens in a patient with Barrett esophagus.". Clin. Genet. 34 (2): 90–7. doi:10.1111/j.1399-0004.1988.tb02842.x. PMID 3191614. 
  • Foltmann B (1989). "Activation of human pepsinogens.". FEBS Lett. 241 (1-2): 69–72. doi:10.1016/0014-5793(88)81033-0. PMID 3197840. 
  • Westerveld BD, Pals G, Bosma A et al. (1987). "Gastric proteases in Barrett's esophagus.". Gastroenterology 93 (4): 774–8. PMID 3305135. 
  • Nakai H, Byers MG, Shows TB, Taggart RT (1987). "Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.". Cytogenet. Cell Genet. 43 (3-4): 215–7. doi:10.1159/000132324. PMID 3467902. 
  • Sogawa K, Fujii-Kuriyama Y, Mizukami Y et al. (1983). "Primary structure of human pepsinogen gene.". J. Biol. Chem. 258 (8): 5306–11. PMID 6300126. 
  • Fujinaga M, Chernaia MM, Tarasova NI et al. (1995). "Crystal structure of human pepsin and its complex with pepstatin.". Protein Sci. 4 (5): 960–72. doi:10.1002/pro.5560040516. PMC 2143119. PMID 7663352. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Zwiers A, ten Dam MA, Crusius JB et al. (1994). "The renal handling of pepsinogen A isozymogens in man.". Clin. Nephrol. 41 (3): 153–8. PMID 8187358. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Plebani M, Basso D, Navaglia F, DiMario F (1998). "Helicobacter pylori genotypes influence serum pepsinogen C levels.". Helicobacter 2 (4): 172–5. doi:10.1111/j.1523-5378.1997.tb00082.x. PMID 9421118. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.