Prostaglandin D2
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(Redirected from PGD2)
| Prostaglandin D2 | |
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| Identifiers | |
| CAS number | 41598-07-6 |
| PubChem | 448457 |
| MeSH | Prostaglandin+D2 |
| IUPHAR ligand | 1881 |
| Properties | |
| Molecular formula | C20H32O5 |
| Molar mass | 352.465 g/mol |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR, as well as CRTH2.[1][2] It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, basophils. In mammalian organs, large amounts of PGD2 are found in the brain, in mast cells and found nowhere else. It is critical to development of allergic diseases such as asthma.
Research carried out in 1989[3] found that PGD2 is the primary mediator of vasodilation (the "niacin flush") after ingestion of niacin (nicotinic acid).
[edit] Effects
- Causes a contraction of the bronchial airways. The concentration of PGD2 in asthma-patients is 10 times higher than in control patients, especially after it is brought into contact with allergens.
- Involved in the regulation of reducing body temperature in sleep, and acts opposite to prostaglandin E2.
- Causes Vasodilation
[edit] See also
[edit] References
- ^ Saito S, Tsuda H, Michimata T (May 2002). "Prostaglandin D2 and reproduction". American Journal of Reproductive Immunology (New York, N.Y. : 1989) 47 (5): 295–302. PMID 12148545. http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1046-7408&date=2002&volume=47&issue=5&spage=295. Retrieved 2011-04-09.
- ^ Pettipher R, Hansel TT (2008). "Antagonists of the prostaglandin D2 receptor CRTH2". Drug News & Perspectives 21 (6): 317–22. doi:10.1358/dnp.2008.21.6.1246831. PMID 18836589. http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=3&p_RefId=1246831. Retrieved 2011-04-09.
- ^ http://www.ncbi.nlm.nih.gov/pubmed/2475889
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