PHA-57378

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PHA-57378
PHA-57378 structure.png
Systematic (IUPAC) name
2,7,8,9,10,11-hexahydro-1H-azepino[4,5-b][1,4]oxazino[2,3,4-hi]indole
Clinical data
Identifiers
303798-94-9 YesY
PubChem CID 10198481
ChemSpider 8373981
Chemical data
Formula C14H16N2O
228.29 g/mol

PHA-57378 is a drug which acts as an agonist at serotonin 5-HT2 receptors,[1] having a binding affinity of 4.1 nM at the 5-HT2A subtype and 4.3 nM at 5-HT2C. It has anxiolytic effects in animal studies.[2]

See also[edit]

References[edit]

  1. ^ Jackson Hester et al. TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS. WIPO Patent Application WO 2000/064899, Priority date April 23, 1999
  2. ^ Ennis, M. D.; Hoffman, R. L.; Ghazal, N. B.; Olson, R. M.; Knauer, C. S.; Chio, C. L.; Hyslop, D. K.; Campbell, J. E.; Fitzgerald, L. W.; Nichols, N. F.; Svensson, K. A.; McCall, R. B.; Haber, C. L.; Kagey, M. L.; Dinh, D. M. (2003). "2,3,4,5-Tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-\1,4]diazepino\1,7-a]indoles: New templates for 5-HT2C agonists". Bioorganic & Medicinal Chemistry Letters 13 (14): 2369–72. doi:10.1016/S0960-894X(03)00403-7. PMID 12824036.  edit