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Polyhomeotic homolog 1 (Drosophila)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PHC1 ; EDR1; HPH1; RAE28
External IDs OMIM602978 HomoloGene107079 GeneCards: PHC1 Gene
RNA expression pattern
PBB GE PHC1 218338 at tn.png
More reference expression data
Species Human Mouse
Entrez 1911 13619
Ensembl ENSG00000111752 ENSMUSG00000040669
UniProt P78364 Q64028
RefSeq (mRNA) NM_004426 NM_001042623
RefSeq (protein) NP_004417 NP_001036088
Location (UCSC) Chr 12:
9.07 – 9.09 Mb
Chr 6:
122.32 – 122.34 Mb
PubMed search [1] [2]

Polyhomeotic-like protein 1 is a protein that in humans is encoded by the PHC1 gene.[1][2]

This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.[2]

Mutations in this gene have been associated to cases of primary microcephaly (doi: 10.1093/hmg/ddt072).


PHC1 has been shown to interact with BMI1[1][3] and PHC2.[1][4]


  1. ^ a b c Gunster MJ, Satijn DP, Hamer KM, den Blaauwen JL, de Bruijn D, Alkema MJ, van Lohuizen M, van Driel R, Otte AP (Apr 1997). "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic". Mol Cell Biol 17 (4): 2326–35. PMC 232081. PMID 9121482. 
  2. ^ a b "Entrez Gene: PHC1 polyhomeotic homolog 1 (Drosophila)". 
  3. ^ Satijn, D P; Gunster M J, van der Vlag J, Hamer K M, Schul W, Alkema M J, Saurin A J, Freemont P S, van Driel R, Otte A P (Jul 1997). "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Mol. Cell. Biol. (UNITED STATES) 17 (7): 4105–13. ISSN 0270-7306. PMC 232264. PMID 9199346. 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]