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Protein inhibitor of activated STAT, 1
Protein PIAS1 PDB 1v66.png
PDB rendering based on 1v66.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603566 MGI1913125 HomoloGene22953 GeneCards: PIAS1 Gene
RNA expression pattern
PBB GE PIAS1 217864 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8554 56469
Ensembl ENSG00000033800 ENSMUSG00000032405
UniProt O75925 O88907
RefSeq (mRNA) NM_016166 NM_019663
RefSeq (protein) NP_057250 NP_062637
Location (UCSC) Chr 15:
68.35 – 68.48 Mb
Chr 9:
62.88 – 62.98 Mb
PubMed search [1] [2]

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.[1][2][3]

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.[3]


PIAS1 has been shown to interact with DNMT3A,[4] STAT1,[5] Small ubiquitin-related modifier 1,[6][7] Sp3 transcription factor,[8] UBE2I[6][7][8] and P53.[7][9]


  1. ^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (September 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A 95 (18): 10626–10631. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754. 
  2. ^ Valdez BC, Henning D, Perlaky L, Busch RK, Busch H (July 1997). "Cloning and characterization of Gu/RH-II binding protein". Biochem Biophys Res Commun 234 (2): 335–340. doi:10.1006/bbrc.1997.6642. PMID 9177271. 
  3. ^ a b "Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1". 
  4. ^ Ling, Yan; Sankpal Umesh T, Robertson Andrea K, McNally James G, Karpova Tatiana, Robertson Keith D (2004). "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription". Nucleic Acids Res. (England) 32 (2): 598–610. doi:10.1093/nar/gkh195. PMC 373322. PMID 14752048. 
  5. ^ Liao, J; Fu Y, Shuai K (May 2000). "Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (10): 5267–5272. doi:10.1073/pnas.97.10.5267. ISSN 0027-8424. PMC 25817. PMID 10805787. 
  6. ^ a b Lee, Byoung-Hee; Yoshimatsu Kumiko, Maeda Akihiko, Ochiai Kazuhiko, Morimatsu Masami, Araki Koichi, Ogino Michiko, Morikawa Shigeru, Arikawa Jiro (December 2003). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. (Netherlands) 98 (1): 83–91. doi:10.1016/j.virusres.2003.09.001. ISSN 0168-1702. PMID 14609633. 
  7. ^ a b c Kahyo, T; Nishida T, Yasuda H (September 2001). "Involvement of PIAS1 in the sumoylation of tumor suppressor p53". Mol. Cell (United States) 8 (3): 713–718. doi:10.1016/S1097-2765(01)00349-5. ISSN 1097-2765. PMID 11583632. 
  8. ^ a b Sapetschnig, Alexandra; Rischitor Grigore, Braun Harald, Doll Andreas, Schergaut Marion, Melchior Frauke, Suske Guntram (October 2002). "Transcription factor Sp3 is silenced through SUMO modification by PIAS1". EMBO J. (England) 21 (19): 5206–5215. doi:10.1093/emboj/cdf510. ISSN 0261-4189. PMC 129032. PMID 12356736. 
  9. ^ Gallagher, W M; Argentini M, Sierra V, Bracco L, Debussche L, Conseiller E (June 1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene (ENGLAND) 18 (24): 3608–3616. doi:10.1038/sj.onc.1202937. ISSN 0950-9232. PMID 10380882. 

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