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Protein inhibitor of activated STAT, 1
Protein PIAS1 PDB 1v66.png
PDB rendering based on 1v66.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603566 MGI1913125 HomoloGene22953 GeneCards: PIAS1 Gene
RNA expression pattern
PBB GE PIAS1 217864 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8554 56469
Ensembl ENSG00000033800 ENSMUSG00000032405
UniProt O75925 O88907
RefSeq (mRNA) NM_016166 NM_019663
RefSeq (protein) NP_057250 NP_062637
Location (UCSC) Chr 15:
68.35 – 68.48 Mb
Chr 9:
62.88 – 62.98 Mb
PubMed search [1] [2]

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.[1][2][3]

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.[3]


PIAS1 has been shown to interact with DNMT3A,[4] STAT1,[5] Small ubiquitin-related modifier 1,[6][7] Sp3 transcription factor,[8] UBE2I[6][7][8] and P53.[7][9]


  1. ^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (September 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A 95 (18): 10626–10631. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754. 
  2. ^ Valdez BC, Henning D, Perlaky L, Busch RK, Busch H (July 1997). "Cloning and characterization of Gu/RH-II binding protein". Biochem Biophys Res Commun 234 (2): 335–340. doi:10.1006/bbrc.1997.6642. PMID 9177271. 
  3. ^ a b "Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1". 
  4. ^ Ling, Yan; Sankpal Umesh T; Robertson Andrea K; McNally James G; Karpova Tatiana; Robertson Keith D (2004). "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription". Nucleic Acids Res. (England) 32 (2): 598–610. doi:10.1093/nar/gkh195. PMC 373322. PMID 14752048. 
  5. ^ Liao, J; Fu Y; Shuai K (May 2000). "Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (10): 5267–5272. doi:10.1073/pnas.97.10.5267. ISSN 0027-8424. PMC 25817. PMID 10805787. 
  6. ^ a b Lee, Byoung-Hee; Yoshimatsu Kumiko; Maeda Akihiko; Ochiai Kazuhiko; Morimatsu Masami; Araki Koichi; Ogino Michiko; Morikawa Shigeru; Arikawa Jiro (December 2003). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. (Netherlands) 98 (1): 83–91. doi:10.1016/j.virusres.2003.09.001. ISSN 0168-1702. PMID 14609633. 
  7. ^ a b c Kahyo, T; Nishida T; Yasuda H (September 2001). "Involvement of PIAS1 in the sumoylation of tumor suppressor p53". Mol. Cell (United States) 8 (3): 713–718. doi:10.1016/S1097-2765(01)00349-5. ISSN 1097-2765. PMID 11583632. 
  8. ^ a b Sapetschnig, Alexandra; Rischitor Grigore; Braun Harald; Doll Andreas; Schergaut Marion; Melchior Frauke; Suske Guntram (October 2002). "Transcription factor Sp3 is silenced through SUMO modification by PIAS1". EMBO J. (England) 21 (19): 5206–5215. doi:10.1093/emboj/cdf510. ISSN 0261-4189. PMC 129032. PMID 12356736. 
  9. ^ Gallagher, W M; Argentini M; Sierra V; Bracco L; Debussche L; Conseiller E (June 1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene (ENGLAND) 18 (24): 3608–3616. doi:10.1038/sj.onc.1202937. ISSN 0950-9232. PMID 10380882. 

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