Protein inhibitor of activated STAT2

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Protein inhibitor of activated STAT, 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PIAS2 ; ARIP3; DIP; MIZ; MIZ1; PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4
External IDs OMIM603567 MGI1096566 HomoloGene20979 GeneCards: PIAS2 Gene
RNA expression pattern
PBB GE PIAS2 37433 at tn.png
PBB GE PIAS2 214442 s at tn.png
PBB GE PIAS2 214593 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9063 17344
Ensembl ENSG00000078043 ENSMUSG00000025423
UniProt O75928 Q8C5D8
RefSeq (mRNA) NM_004671 NM_001164167
RefSeq (protein) NP_004662 NP_001157639
Location (UCSC) Chr 18:
44.39 – 44.5 Mb
Chr 18:
77.07 – 77.16 Mb
PubMed search [1] [2]

E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene.[1][2][3]


Interactions[edit]

Protein inhibitor of activated STAT2 has been shown to interact with Androgen receptor,[4][5] DNMT3A,[6] PARK7[7] and UBE2I.[8][9]

References[edit]

  1. ^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (September 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A 95 (18): 10626–31. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754. 
  2. ^ Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R (September 1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA". Mech Dev 65 (1–2): 3–17. doi:10.1016/S0925-4773(97)00032-4. PMID 9256341. 
  3. ^ "Entrez Gene: PIAS2 protein inhibitor of activated STAT, 2". 
  4. ^ Kotaja, N; Aittomäki S; Silvennoinen O; Palvimo J J; Jänne O A (December 2000). "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation". Mol. Endocrinol. (United States) 14 (12): 1986–2000. doi:10.1210/me.14.12.1986. ISSN 0888-8809. PMID 11117529. 
  5. ^ Moilanen, A M; Karvonen U; Poukka H; Yan W; Toppari J; Jänne O A; Palvimo J J (February 1999). "A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins". J. Biol. Chem. (UNITED STATES) 274 (6): 3700–4. doi:10.1074/jbc.274.6.3700. ISSN 0021-9258. PMID 9920921. 
  6. ^ Ling, Yan; Sankpal Umesh T; Robertson Andrea K; McNally James G; Karpova Tatiana; Robertson Keith D (2004). "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription". Nucleic Acids Res. (England) 32 (2): 598–610. doi:10.1093/nar/gkh195. PMC 373322. PMID 14752048. 
  7. ^ Takahashi, K; Taira T; Niki T; Seino C; Iguchi-Ariga S M; Ariga H (October 2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". J. Biol. Chem. (United States) 276 (40): 37556–63. doi:10.1074/jbc.M101730200. ISSN 0021-9258. PMID 11477070. 
  8. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  9. ^ Lee, Byoung-Hee; Yoshimatsu Kumiko; Maeda Akihiko; Ochiai Kazuhiko; Morimatsu Masami; Araki Koichi; Ogino Michiko; Morikawa Shigeru; Arikawa Jiro (December 2003). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. (Netherlands) 98 (1): 83–91. doi:10.1016/j.virusres.2003.09.001. ISSN 0168-1702. PMID 14609633. 

Further reading[edit]