PICALM

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Phosphatidylinositol binding clathrin assembly protein
Protein PICALM PDB 1hf8.png
PDB rendering based on 1hf8.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PICALM ; CALM; CLTH; LAP
External IDs OMIM603025 MGI2385902 HomoloGene111783 GeneCards: PICALM Gene
RNA expression pattern
PBB GE PICALM 212506 at tn.png
PBB GE PICALM 212511 at tn.png
PBB GE PICALM 215236 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8301 233489
Ensembl ENSG00000073921 ENSMUSG00000039361
UniProt Q13492 Q7M6Y3
RefSeq (mRNA) NM_001008660 NM_001252520
RefSeq (protein) NP_001008660 NP_001239449
Location (UCSC) Chr 11:
85.67 – 85.78 Mb
Chr 7:
90.13 – 90.21 Mb
PubMed search [1] [2]

Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene.[1]


Interactions[edit]

PICALM has been shown to interact with CLTC.[2]

Clinical significance[edit]

In humans, certain alleles of this gene have been statistically associated with an increased risk of developing late-onset Alzheimer's disease.[3]

References[edit]

Further reading[edit]