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Protein interacting with PRKCA 1
Protein PICK1 PDB 2gzv.png
PDB rendering based on 2gzv.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM605926 MGI894645 HomoloGene7470 GeneCards: PICK1 Gene
RNA expression pattern
PBB GE PICK1 204746 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9463 18693
Ensembl ENSG00000100151 ENSMUSG00000068206
UniProt Q9NRD5 Q62083
RefSeq (mRNA) NM_001039583 NM_001045558
RefSeq (protein) NP_001034672 NP_001039023
Location (UCSC) Chr 22:
38.06 – 38.08 Mb
Chr 15:
79.23 – 79.26 Mb
PubMed search [1] [2]

PRKCA-binding protein is a protein that in humans is encoded by the PICK1 gene.[1][2]


The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.[3]


PICK1 has been shown to interact with:


  1. ^ Dev KK, Nishimune A, Henley JM, Nakanishi S (July 1999). "The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits". Neuropharmacology 38 (5): 635–44. doi:10.1016/S0028-3908(98)00230-5. PMID 10340301. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (December 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ "Entrez Gene: PICK1 protein interacting with PRKCA 1". 
  4. ^ Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA et al. (February 2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. doi:10.1073/pnas.252782799. PMC 149953. PMID 12578970. 
  5. ^ a b Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (February 2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773. 
  6. ^ Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI et al. (April 2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron 30 (1): 121–34. doi:10.1016/s0896-6273(01)00267-7. PMID 11343649. 
  7. ^ a b c d e Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM et al. (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216. 
  8. ^ a b Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C et al. (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron 37 (4): 625–38. doi:10.1016/s0896-6273(02)01191-1. PMC 3314502. PMID 12597860. 
  9. ^ Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D et al. (May 2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603. 
  10. ^ Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S (October 2000). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. PMID 11007882. 

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