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Phosphatidylinositol glycan anchor biosynthesis, class C
Symbols PIGC ; GPI2
External IDs OMIM601730 MGI1914542 HomoloGene7109 GeneCards: PIGC Gene
EC number
RNA expression pattern
PBB GE PIGC 202846 s at tn.png
PBB GE PIGC 216593 s at tn.png
PBB GE PIGC 215242 at tn.png
More reference expression data
Species Human Mouse
Entrez 5279 67292
Ensembl ENSG00000135845 ENSMUSG00000026698
UniProt Q92535 Q9CXR4
RefSeq (mRNA) NM_002642 NM_001039045
RefSeq (protein) NP_002633 NP_001034134
Location (UCSC) Chr 1:
172.34 – 172.41 Mb
Chr 1:
161.97 – 162.03 Mb
PubMed search [1] [2]

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.[1][2][3]

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized.[3]


PIGC has been shown to interact with PIGQ.[4]


  1. ^ Inoue N, Watanabe R, Takeda J, Kinoshita T (Oct 1996). "PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2". Biochem Biophys Res Commun 226 (1): 193–9. doi:10.1006/bbrc.1996.1332. PMID 8806613. 
  2. ^ Hong Y, Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Nov 1997). "Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1". Genomics 44 (3): 347–9. doi:10.1006/geno.1997.4893. PMID 9325057. 
  3. ^ a b "Entrez Gene: PIGC phosphatidylinositol glycan anchor biosynthesis, class C". 
  4. ^ Watanabe, R; Inoue N; Westfall B; Taron C H; Orlean P; Takeda J; Kinoshita T (Feb 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. (ENGLAND) 17 (4): 877–85. doi:10.1093/emboj/17.4.877. ISSN 0261-4189. PMC 1170437. PMID 9463366. 

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