PIGF

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Phosphatidylinositol glycan anchor biosynthesis, class F
Identifiers
Symbols PIGF ; MGC32646; MGC33136
External IDs OMIM600153 MGI99462 HomoloGene31103 GeneCards: PIGF Gene
EC number 2.7.8.1
RNA expression pattern
PBB GE PIGF 205077 s at tn.png
PBB GE PIGF 205078 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5281 18701
Ensembl ENSG00000151665 ENSMUSG00000024145
UniProt Q07326 O09101
RefSeq (mRNA) NM_002643 NM_008838
RefSeq (protein) NP_002634 NP_032864
Location (UCSC) Chr 2:
46.81 – 46.84 Mb
Chr 17:
87 – 87.03 Mb
PubMed search [1] [2]

Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.[1][2][3]

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least two alternatively spliced transcripts encoding distinct isoforms have been found for this gene.[3]

References[edit]

  1. ^ Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Mar 1996). "Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF". Genomics 29 (3): 804–7. doi:10.1006/geno.1995.9929. PMID 8575782. 
  2. ^ Inoue N, Kinoshita T, Orii T, Takeda J (May 1993). "Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy". J Biol Chem 268 (10): 6882–5. PMID 8463218. 
  3. ^ a b "Entrez Gene: PIGF phosphatidylinositol glycan anchor biosynthesis, class F". 

Further reading[edit]