PIGH

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Phosphatidylinositol glycan anchor biosynthesis, class H
Identifiers
Symbols PIGH ; GPI-H
External IDs OMIM600154 MGI99463 HomoloGene3361 GeneCards: PIGH Gene
EC number 2.4.1.198
RNA expression pattern
PBB GE PIGH 209625 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5283 110417
Ensembl ENSG00000100564 ENSMUSG00000021120
UniProt Q14442 Q5M9N4
RefSeq (mRNA) NM_004569 NM_029988
RefSeq (protein) NP_004560 NP_084264
Location (UCSC) Chr 14:
68.05 – 68.07 Mb
Chr 12:
79.08 – 79.09 Mb
PubMed search [1] [2]

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene.[1][2] The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.[3]

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum.[2]

Interactions[edit]

PIGH has been shown to interact with PIGQ.[4]

References[edit]

  1. ^ Ware RE, Howard TA, Kamitani T, Change HM, Yeh ET, Seldin MF (Jul 1994). "Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria". Blood 83 (12): 3753–7. PMID 8204896. 
  2. ^ a b "Entrez Gene: PIGH phosphatidylinositol glycan anchor biosynthesis, class H". 
  3. ^ "AceView: Homo sapiens gene PIGH". AceView. National Library of Medicine. Retrieved 24 April 2011. 
  4. ^ Watanabe, R; Inoue N; Westfall B; Taron C H; Orlean P; Takeda J; Kinoshita T (Feb 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. (ENGLAND) 17 (4): 877–85. doi:10.1093/emboj/17.4.877. ISSN 0261-4189. PMC 1170437. PMID 9463366. 

Further reading[edit]