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Phosphatidylinositol glycan anchor biosynthesis, class K
Symbols PIGK ; GPI8
External IDs OMIM605087 MGI1913863 HomoloGene4002 GeneCards: PIGK Gene
EC number 3.-.-.-
RNA expression pattern
PBB GE PIGK 209707 at tn.png
More reference expression data
Species Human Mouse
Entrez 10026 329777
Ensembl ENSG00000142892 ENSMUSG00000039047
UniProt Q92643 Q9CXY9
RefSeq (mRNA) NM_005482 NM_025662
RefSeq (protein) NP_005473 NP_079938
Location (UCSC) Chr 1:
77.55 – 77.69 Mb
Chr 3:
152.71 – 152.98 Mb
PubMed search [1] [2]

GPI-anchor transamidase is an enzyme that in humans is encoded by the PIGK gene.[1][2]

This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.[2]


PIGK has been shown to interact with PIGT[3] and GPAA1.[4][5]


  1. ^ Yu J, Nagarajan S, Knez JJ, Udenfriend S, Chen R, Medof ME (December 1997). "The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase". Proc Natl Acad Sci U S A 94 (23): 12580–5. doi:10.1073/pnas.94.23.12580. PMC 25045. PMID 9356492. 
  2. ^ a b "Entrez Gene: PIGK phosphatidylinositol glycan anchor biosynthesis, class K". 
  3. ^ Ohishi, Kazuhito; Nagamune Kisaburo; Maeda Yusuke; Kinoshita Taroh (April 2003). "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge". J. Biol. Chem. (United States) 278 (16): 13959–67. doi:10.1074/jbc.M300586200. ISSN 0021-9258. PMID 12582175. 
  4. ^ Ohishi, K; Inoue N; Maeda Y; Takeda J; Riezman H; Kinoshita T (May 2000). "Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins". Mol. Biol. Cell (UNITED STATES) 11 (5): 1523–33. doi:10.1091/mbc.11.5.1523. ISSN 1059-1524. PMC 14864. PMID 10793132. 
  5. ^ Vainauskas, Saulius; Maeda Yusuke; Kurniawan Henry; Kinoshita Taroh; Menon Anant K (August 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. (United States) 277 (34): 30535–42. doi:10.1074/jbc.M205402200. ISSN 0021-9258. PMID 12052837. 

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