PIGQ

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Phosphatidylinositol glycan anchor biosynthesis, class Q
Identifiers
Symbols PIGQ ; GPI1; c407A10.1
External IDs OMIM605754 MGI1333114 HomoloGene31228 GeneCards: PIGQ Gene
EC number 2.4.1.198
RNA expression pattern
PBB GE PIGQ 204144 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9091 14755
Ensembl ENSG00000007541 ENSMUSG00000025728
UniProt Q9BRB3 Q9QYT7
RefSeq (mRNA) NM_004204 NM_011822
RefSeq (protein) NP_004195 NP_035952
Location (UCSC) Chr 16:
0.62 – 0.63 Mb
Chr 17:
25.93 – 25.94 Mb
PubMed search [1] [2]

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.[1][2][3]

This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).[3]

Interactions[edit]

PIGQ has been shown to interact with PIGH,[1] PIGA[1] and PIGC.[1]

References[edit]

  1. ^ a b c d Watanabe R, Inoue N, Westfall B, Taron CH, Orlean P, Takeda J, Kinoshita T (Mar 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J 17 (4): 877–85. doi:10.1093/emboj/17.4.877. PMC 1170437. PMID 9463366. 
  2. ^ Tiede A, Schubert J, Nischan C, Jensen I, Westfall B, Taron CH, Orlean P, Schmidt RE (Nov 1998). "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants". Biochem J 334 (3): 609–16. PMC 1219730. PMID 9729469. 
  3. ^ a b "Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q". 

Further reading[edit]