PIGT

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Phosphatidylinositol glycan anchor biosynthesis, class T
Identifiers
Symbols PIGT ; NDAP
External IDs OMIM610272 MGI1926178 HomoloGene6134 GeneCards: PIGT Gene
RNA expression pattern
PBB GE PIGT 217770 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51604 78928
Ensembl ENSG00000124155 ENSMUSG00000017721
UniProt Q969N2 Q8BXQ2
RefSeq (mRNA) NM_001184728 NM_133779
RefSeq (protein) NP_001171657 NP_598540
Location (UCSC) Chr 20:
44.04 – 44.05 Mb
Chr 2:
164.5 – 164.51 Mb
PubMed search [1] [2]

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.[1][2][3]

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.[2]

Interactions[edit]

PIGT has been shown to interact with PIGK[4] and GPAA1.[3][5]

References[edit]

  1. ^ Vainauskas S, Menon AK (Apr 2005). "Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex". J Biol Chem 280 (16): 16402–9. doi:10.1074/jbc.M414253200. PMID 15713669. 
  2. ^ a b "Entrez Gene: PIGT phosphatidylinositol glycan anchor biosynthesis, class T". 
  3. ^ a b Ohishi K, Inoue N, Kinoshita T (August 2001). "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8". EMBO J. 20 (15): 4088–98. doi:10.1093/emboj/20.15.4088. PMC 149153. PMID 11483512. 
  4. ^ Ohishi, Kazuhito; Nagamune Kisaburo, Maeda Yusuke, Kinoshita Taroh (Apr 2003). "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge". J. Biol. Chem. (United States) 278 (16): 13959–67. doi:10.1074/jbc.M300586200. ISSN 0021-9258. PMID 12582175. 
  5. ^ Vainauskas, Saulius; Maeda Yusuke, Kurniawan Henry, Kinoshita Taroh, Menon Anant K (Aug 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. (United States) 277 (34): 30535–42. doi:10.1074/jbc.M205402200. ISSN 0021-9258. PMID 12052837. 

Further reading[edit]