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Phosphatidylinositol glycan anchor biosynthesis, class U
Symbols PIGU ; CDC91L1; GAB1
External IDs OMIM608528 MGI3039607 HomoloGene6553 GeneCards: PIGU Gene
Species Human Mouse
Entrez 128869 228812
Ensembl ENSG00000101464 ENSMUSG00000038383
UniProt Q9H490 Q8K358
RefSeq (mRNA) NM_080476 NM_001004721
RefSeq (protein) NP_536724 NP_001004721
Location (UCSC) Chr 20:
33.15 – 33.26 Mb
Chr 2:
155.28 – 155.36 Mb
PubMed search [1] [2]

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.[1][2][3]

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.[3]


  1. ^ Hong Y, Ohishi K, Kang JY, Tanaka S, Inoue N, Nishimura J, Maeda Y, Kinoshita T (Jun 2003). "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins". Mol Biol Cell 14 (5): 1780–9. doi:10.1091/mbc.E02-12-0794. PMC 165076. PMID 12802054. 
  2. ^ Guo Z, Linn JF, Wu G, Anzick SL, Eisenberger CF, Halachmi S, Cohen Y, Fomenkov A, Hoque MO, Okami K, Steiner G, Engles JM, Osada M, Moon C, Ratovitski E, Trent JM, Meltzer PS, Westra WH, Kiemeney LA, Schoenberg MP, Sidransky D, Trink B (Apr 2004). "CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer". Nat Med 10 (4): 374–81. doi:10.1038/nm1010. PMID 15034568. 
  3. ^ a b "Entrez Gene: PIGU phosphatidylinositol glycan anchor biosynthesis, class U". 

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