PIK3C2B

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Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Identifiers
Symbols PIK3C2B ; C2-PI3K
External IDs OMIM602838 MGI2685045 HomoloGene20582 ChEMBL: 5554 GeneCards: PIK3C2B Gene
EC number 2.7.1.154
RNA expression pattern
PBB GE PIK3C2B 204484 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5287 240752
Ensembl ENSG00000133056 ENSMUSG00000026447
UniProt O00750 E9QAN8
RefSeq (mRNA) NM_002646 NM_001099276
RefSeq (protein) NP_002637 NP_001092746
Location (UCSC) Chr 1:
204.39 – 204.46 Mb
Chr 1:
133.05 – 133.11 Mb
PubMed search [1] [2]

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the PIK3C2B gene.[1][2][3]

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.[3]

References[edit]

  1. ^ Brown RA, Ho LK, Weber-Hall SJ, Shipley JM, Fry MJ (Jun 1997). "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K". Biochem Biophys Res Commun 233 (2): 537–44. doi:10.1006/bbrc.1997.6495. PMID 9144573. 
  2. ^ Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD (Jan 1999). "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity". J Biol Chem 273 (49): 33082–90. doi:10.1074/jbc.273.49.33082. PMID 9830063. 
  3. ^ a b "Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide". 

Further reading[edit]