PIR (gene)

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Pirin (iron-binding nuclear protein)
Protein PIR PDB 1j1l.png
PDB rendering based on 1j1l.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol PIR
External IDs OMIM603329 MGI1916906 HomoloGene2717 GeneCards: PIR Gene
EC number
RNA expression pattern
PBB GE PIR 207469 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8544 69656
Ensembl ENSG00000087842 ENSMUSG00000031379
UniProt O00625 Q9D711
RefSeq (mRNA) NM_001018109 NM_027153
RefSeq (protein) NP_001018119 NP_081429
Location (UCSC) Chr X:
15.4 – 15.51 Mb
Chr X:
164.27 – 164.37 Mb
PubMed search [1] [2]

Pirin is a protein that in humans is encoded by the PIR gene.[1][2]

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.[2]


PIR (gene) has been shown to interact with BCL3.[3]


  1. ^ Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein". J Biol Chem 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676. 
  2. ^ a b "Entrez Gene: PIR pirin (iron-binding nuclear protein)". 
  3. ^ Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene (ENGLAND) 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. ISSN 0950-9232. PMID 10362352. 

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