From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protein kinase N2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PKN2 ; PAK2; PRK2; PRKCL2; PRO2042; Pak-2; STK7
External IDs OMIM602549 MGI109211 HomoloGene2054 ChEMBL: 3032 GeneCards: PKN2 Gene
EC number
RNA expression pattern
PBB GE PKN2 210969 at tn.png
PBB GE PKN2 212628 at tn.png
PBB GE PKN2 212629 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5586 109333
Ensembl ENSG00000065243 ENSMUSG00000004591
UniProt Q16513 Q8BWW9
RefSeq (mRNA) NM_006256 NM_178654
RefSeq (protein) NP_006247 NP_848769
Location (UCSC) Chr 1:
89.15 – 89.3 Mb
Chr 3:
142.79 – 142.88 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase N2 is an enzyme that in humans is encoded by the PKN2 gene.[1][2][3]


PKN2 has been shown to interact with Phosphoinositide-dependent kinase-1,[4][5] AKT1,[6] NCK1,[7][8] PTPN13[9] and RHOA.[7][10]

Further reading[edit]

  1. ^ Palmer RH, Ridden J, Parker PJ (January 1995). "Identification of multiple, novel, protein kinase C-related gene products". FEBS Lett 356 (1): 5–8. doi:10.1016/0014-5793(94)01202-4. PMID 7988719. 
  2. ^ Palmer RH, Ridden J, Parker PJ (March 1995). "Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family". Eur J Biochem 227 (1–2): 344–351. doi:10.1111/j.1432-1033.1995.tb20395.x. PMID 7851406. 
  3. ^ "Entrez Gene: PKN2 protein kinase N2". 
  4. ^ Hodgkinson, Conrad P; Sale Graham J (January 2002). "Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment". Biochemistry (United States) 41 (2): 561–569. doi:10.1021/bi010719z. ISSN 0006-2960. PMID 11781095. 
  5. ^ Balendran, A; Biondi R M; Cheung P C; Casamayor A; Deak M; Alessi D R (July 2000). "A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1". J. Biol. Chem. (UNITED STATES) 275 (27): 20806–20813. doi:10.1074/jbc.M000421200. ISSN 0021-9258. PMID 10764742. 
  6. ^ Koh, H; Lee K H; Kim D; Kim S; Kim J W; Chung J (November 2000). "Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage". J. Biol. Chem. (UNITED STATES) 275 (44): 34451–34458. doi:10.1074/jbc.M001753200. ISSN 0021-9258. PMID 10926925. 
  7. ^ a b Quilliam, L A; Lambert Q T; Mickelson-Young L A; Westwick J K; Sparks A B; Kay B K; Jenkins N A; Gilbert D J; Copeland N G; Der C J (November 1996). "Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling". J. Biol. Chem. (UNITED STATES) 271 (46): 28772–28776. doi:10.1074/jbc.271.46.28772. ISSN 0021-9258. PMID 8910519. 
  8. ^ Braverman, L E; Quilliam L A (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". J. Biol. Chem. (UNITED STATES) 274 (9): 5542–5549. doi:10.1074/jbc.274.9.5542. ISSN 0021-9258. PMID 10026169. 
  9. ^ Gross, C; Heumann R; Erdmann K S (May 2001). "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif". FEBS Lett. (Netherlands) 496 (2–3): 101–104. doi:10.1016/S0014-5793(01)02401-2. ISSN 0014-5793. PMID 11356191. 
  10. ^ Flynn, P; Mellor H; Palmer R; Panayotou G; Parker P J (January 1998). "Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif". J. Biol. Chem. (UNITED STATES) 273 (5): 2698–2705. doi:10.1074/jbc.273.5.2698. ISSN 0021-9258. PMID 9446575.