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Phospholipase A2, group X
Protein PLA2G10 PDB 1le6.png
PDB rendering based on 1le6.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PLA2G10 ; GXPLA2; GXSPLA2; SPLA2
External IDs OMIM603603 MGI1347522 HomoloGene2636 IUPHAR: 1422 ChEMBL: 4342 GeneCards: PLA2G10 Gene
EC number
RNA expression pattern
PBB GE PLA2G10 207222 at tn.png
More reference expression data
Species Human Mouse
Entrez 8399 26565
Ensembl ENSG00000069764 ENSMUSG00000022683
UniProt O15496 Q9QXX3
RefSeq (mRNA) NM_003561 NM_001291009
RefSeq (protein) NP_003552 NP_001277938
Location (UCSC) Chr 16:
14.77 – 14.79 Mb
Chr 16:
13.72 – 13.73 Mb
PubMed search [1] [2]

Group 10 secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G10 gene.[1][2]


  1. ^ Cupillard L, Koumanov K, Mattei MG, Lazdunski M, Lambeau G (Jul 1997). "Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2". J Biol Chem 272 (25): 15745–52. doi:10.1074/jbc.272.25.15745. PMID 9188469. 
  2. ^ "Entrez Gene: PLA2G10 phospholipase A2, group X". 

Further reading[edit]

  • Schröder HC, Perovic S, Kavsan V et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology 19 (4-5): 683–8. PMID 9745929. 
  • Sartipy P, Camejo G, Svensson L, Hurt-Camejo E (2003). "Phospholipase A2 modification of lipoproteins: potential effects on atherogenesis.". Adv. Exp. Med. Biol. 507: 3–7. doi:10.1007/978-1-4615-0193-0_1. PMID 12664556. 
  • Murakami M, Kudo I (2004). "New phospholipase A(2) isozymes with a potential role in atherosclerosis.". Curr. Opin. Lipidol. 14 (5): 431–6. doi:10.1097/01.mol.0000092629.86399.d6. PMID 14501581. 
  • Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression.". Genomics 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505. 
  • Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118. 
  • Yokota Y, Higashino K, Nakano K et al. (2000). "Identification of group X secretory phospholipase A(2) as a natural ligand for mouse phospholipase A(2) receptor.". FEBS Lett. 478 (1-2): 187–91. doi:10.1016/S0014-5793(00)01848-2. PMID 10922494. 
  • Morioka Y, Saiga A, Yokota Y et al. (2000). "Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor.". Arch. Biochem. Biophys. 381 (1): 31–42. doi:10.1006/abbi.2000.1977. PMID 11019817. 
  • Degousee N, Ghomashchi F, Stefanski E et al. (2002). "Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis.". J. Biol. Chem. 277 (7): 5061–73. doi:10.1074/jbc.M109083200. PMID 11741884. 
  • Hanasaki K, Yamada K, Yamamoto S et al. (2002). "Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation.". J. Biol. Chem. 277 (32): 29116–24. doi:10.1074/jbc.M202867200. PMID 12021277. 
  • Osterström A, Dimberg J, Fransén K, Söderkvist P (2002). "Expression of cytosolic and group X secretory phospholipase A(2) genes in human colorectal adenocarcinomas.". Cancer Lett. 182 (2): 175–82. doi:10.1016/S0304-3835(02)00081-2. PMID 12048163. 
  • Pan YH, Yu BZ, Singer AG et al. (2002). "Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.". J. Biol. Chem. 277 (32): 29086–93. doi:10.1074/jbc.M202531200. PMID 12161451. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Wooton-Kee CR, Boyanovsky BB, Nasser MS et al. (2004). "Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation.". Arterioscler. Thromb. Vasc. Biol. 24 (4): 762–7. doi:10.1161/01.ATV.0000122363.02961.c1. PMID 14962950. 
  • Mounier CM, Ghomashchi F, Lindsay MR et al. (2004). "Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha.". J. Biol. Chem. 279 (24): 25024–38. doi:10.1074/jbc.M313019200. PMID 15007070. 
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Masuda S, Murakami M, Takanezawa Y et al. (2005). "Neuronal expression and neuritogenic action of group X secreted phospholipase A2.". J. Biol. Chem. 280 (24): 23203–14. doi:10.1074/jbc.M500985200. PMID 15781456.