PLA2G4A

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Phospholipase A2, group IVA (cytosolic, calcium-dependent)
Protein PLA2G4A PDB 1bci.png
PDB rendering based on 1bci.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PLA2G4A ; PLA2G4; cPLA2-alpha
External IDs OMIM600522 MGI1195256 HomoloGene32059 ChEMBL: 3816 GeneCards: PLA2G4A Gene
EC number 3.1.1.4, 3.1.1.5
RNA expression pattern
PBB GE PLA2G4A 210145 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5321 18783
Ensembl ENSG00000116711 ENSMUSG00000056220
UniProt P47712 P47713
RefSeq (mRNA) NM_024420 NM_008869
RefSeq (protein) NP_077734 NP_032895
Location (UCSC) Chr 1:
186.8 – 186.96 Mb
Chr 1:
149.83 – 149.96 Mb
PubMed search [1] [2]

Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene.[1][2]

Function[edit]

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.[2]

Interactions[edit]

PLA2G4A has been shown to interact with HTATIP.[3]

Clinical signficance[edit]

Mutations in this gene have been associated with multifocal stenosing ulceration of the small intestine.[4]

References[edit]

  1. ^ Dennis EA (Jun 1994). "Diversity of group types, regulation, and function of phospholipase A2". J Biol Chem 269 (18): 13057–60. PMID 8175726. 
  2. ^ a b "Entrez Gene: PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)". 
  3. ^ Sheridan AM, Force T, Yoon HJ, O'Leary E, Choukroun G, Taheri MR, Bonventre JV (July 2001). "PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production". Mol. Cell. Biol. 21 (14): 4470–81. doi:10.1128/MCB.21.14.4470-4481.2001. PMC 87107. PMID 11416127. 
  4. ^ Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP, Macdonald TT (December 2012). "Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α". Gut. doi:10.1136/gutjnl-2012-303581. PMID 23268370. 

Further reading[edit]