PLA2G6

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Phospholipase A2, group VI (cytosolic, calcium-independent)
Identifiers
Symbols PLA2G6 ; CaI-PLA2; GVI; INAD1; IPLA2-VIA; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PNPLA9; iPLA2; iPLA2beta
External IDs OMIM603604 MGI1859152 HomoloGene2635 IUPHAR: 1431 ChEMBL: 3213 GeneCards: PLA2G6 Gene
EC number 3.1.1.4
RNA expression pattern
PBB GE PLA2G6 215938 s at tn.png
PBB GE PLA2G6 204691 x at tn.png
PBB GE PLA2G6 210647 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8398 53357
Ensembl ENSG00000184381 ENSMUSG00000042632
UniProt O60733 P97819
RefSeq (mRNA) NM_001004426 NM_001199023
RefSeq (protein) NP_001004426 NP_001185952
Location (UCSC) Chr 22:
38.51 – 38.6 Mb
Chr 15:
79.29 – 79.33 Mb
PubMed search [1] [2]

85 kDa calcium-independent phospholipase A2 is an enzyme that in humans is encoded by the PLA2G6 gene.[1][2][3][4]

The protein encoded by this gene is a phospholipase A2 enzyme, a subclass of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, Fas receptor-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.[4]

Model organisms[edit]

Model organisms have been used in the study of PLA2G6 function. A conditional knockout mouse line called Pla2g6tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]



References[edit]

  1. ^ Larsson PK, Claesson HE, Kennedy BP (Feb 1998). "Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity". J Biol Chem 273 (1): 207–14. doi:10.1074/jbc.273.1.207. PMID 9417066. 
  2. ^ Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family". J Lipid Res 47 (9): 1940–9. doi:10.1194/jlr.M600185-JLR200. PMID 16799181. 
  3. ^ Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl: S63–8. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121. 
  4. ^ a b "Entrez Gene: PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)". 
  5. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  6. ^ a b "International Mouse Phenotyping Consortium". 
  7. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  8. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  9. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  10. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  11. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]