PLA2G6

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Phospholipase A2, group VI (cytosolic, calcium-independent)
Identifiers
Symbols PLA2G6 ; CaI-PLA2; GVI; INAD1; IPLA2-VIA; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PNPLA9; iPLA2; iPLA2beta
External IDs OMIM603604 MGI1859152 HomoloGene2635 ChEMBL: 3213 GeneCards: PLA2G6 Gene
EC number 3.1.1.4
RNA expression pattern
PBB GE PLA2G6 215938 s at tn.png
PBB GE PLA2G6 204691 x at tn.png
PBB GE PLA2G6 210647 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8398 53357
Ensembl ENSG00000184381 ENSMUSG00000042632
UniProt O60733 P97819
RefSeq (mRNA) NM_001004426 NM_001199023
RefSeq (protein) NP_001004426 NP_001185952
Location (UCSC) Chr 22:
38.51 – 38.6 Mb
Chr 15:
79.29 – 79.33 Mb
PubMed search [1] [2]

85 kDa calcium-independent phospholipase A2 is an enzyme that in humans is encoded by the PLA2G6 gene.[1][2][3][4]

The protein encoded by this gene is a phospholipase A2 enzyme, a subclass of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, Fas receptor-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.[4]

References[edit]

  1. ^ Larsson PK, Claesson HE, Kennedy BP (Feb 1998). "Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity". J Biol Chem 273 (1): 207–14. doi:10.1074/jbc.273.1.207. PMID 9417066. 
  2. ^ Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family". J Lipid Res 47 (9): 1940–9. doi:10.1194/jlr.M600185-JLR200. PMID 16799181. 
  3. ^ Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl: S63–8. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121. 
  4. ^ a b "Entrez Gene: PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)". 

Further reading[edit]