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Pleiomorphic adenoma gene-like 1
Symbols PLAGL1 ; LOT1; ZAC; ZAC1
External IDs OMIM603044 HomoloGene31401 GeneCards: PLAGL1 Gene
RNA expression pattern
PBB GE PLAGL1 207002 s at tn.png
PBB GE PLAGL1 207943 x at tn.png
PBB GE PLAGL1 209318 x at tn.png
More reference expression data
Species Human Mouse
Entrez 5325 22634
Ensembl ENSG00000118495 ENSMUSG00000019817
UniProt Q9UM63 n/a
RefSeq (mRNA) NM_001080951 NM_009538
RefSeq (protein) NP_001074420 NP_033564
Location (UCSC) Chr 6:
144.26 – 144.39 Mb
Chr 10:
13.09 – 13.13 Mb
PubMed search [1] [2]

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.[1][2][3]


This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.[3]


PLAGL1 has been shown to interact with P53.[4]


  1. ^ Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527. 
  2. ^ Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C et al. (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. doi:10.1073/pnas.95.15.8835. PMC 21163. PMID 9671765. 
  3. ^ a b "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1". 
  4. ^ Huang SM, Schönthal AH, Stallcup MR (Apr 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197. 

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