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Pleiomorphic adenoma gene-like 1
Symbols PLAGL1 ; LOT1; ZAC; ZAC1
External IDs OMIM603044 HomoloGene31401 GeneCards: PLAGL1 Gene
RNA expression pattern
PBB GE PLAGL1 207002 s at tn.png
PBB GE PLAGL1 207943 x at tn.png
PBB GE PLAGL1 209318 x at tn.png
More reference expression data
Species Human Mouse
Entrez 5325 22634
Ensembl ENSG00000118495 ENSMUSG00000019817
UniProt Q9UM63 n/a
RefSeq (mRNA) NM_001080951 NM_009538
RefSeq (protein) NP_001074420 NP_033564
Location (UCSC) Chr 6:
144.26 – 144.39 Mb
Chr 10:
13.09 – 13.13 Mb
PubMed search [1] [2]

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.[1][2][3]

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.[3]


PLAGL1 has been shown to interact with P53.[4]


  1. ^ Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J Biol Chem 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527. 
  2. ^ Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc Natl Acad Sci U S A 95 (15): 8835–40. doi:10.1073/pnas.95.15.8835. PMC 21163. PMID 9671765. 
  3. ^ a b "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1". 
  4. ^ Huang, S M; Schönthal A H; Stallcup M R (Apr 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene (England) 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. ISSN 0950-9232. PMID 11360197. 

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