PLCB2

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Phospholipase C, beta 2
Protein PLCB2 PDB 2fju.png
PDB rendering based on 2fju.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PLCB2 ; PLC-beta-2
External IDs OMIM604114 MGI107465 HomoloGene20957 IUPHAR: 1404 ChEMBL: 3620 GeneCards: PLCB2 Gene
EC number 3.1.4.11
RNA expression pattern
PBB GE PLCB2 204046 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5330 18796
Ensembl ENSG00000137841 ENSMUSG00000040061
UniProt Q00722 A3KGF7
RefSeq (mRNA) NM_001284297 NM_001290790
RefSeq (protein) NP_001271226 NP_001277719
Location (UCSC) Chr 15:
40.57 – 40.6 Mb
Chr 2:
118.71 – 118.73 Mb
PubMed search [1] [2]

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.[1][2][3]

Function[edit]

The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions[edit]

PLCB2 has been shown to interact with MAP2K3[4] and TRPM7.[5]

References[edit]

  1. ^ Park D, Jhon DY, Kriz R, Knopf J, Rhee SG (Sep 1992). "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2". J. Biol. Chem. 267 (23): 16048–55. PMID 1644792. 
  2. ^ Park SH, Ryu SH, Suh PG, Kim H (Mar 1999). "Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 83 (1-2): 48–9. doi:10.1159/000015166. PMID 9925923.  Check date values in: |year= / |date= mismatch (help)
  3. ^ "Entrez Gene: PLCB2 phospholipase C, beta 2". 
  4. ^ Barr AJ, Marjoram R, Xu J, Snyderman R (Apr 2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3". Biochem. Biophys. Res. Commun. 293 (1): 647–52. doi:10.1016/S0006-291X(02)00259-0. PMID 12054652. 
  5. ^ Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371. 

Further reading[edit]

  • Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339. 
  • Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147. 
  • Buhl AM, Osawa S, Johnson GL (1995). "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor". J. Biol. Chem. 270 (34): 19828–32. doi:10.1074/jbc.270.34.19828. PMID 7649993. 
  • Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385. 
  • Darè E, Kifor O, Brown EM, Weber G (1998). "Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor". J. Mol. Endocrinol. 21 (1): 7–17. doi:10.1677/jme.0.0210007. PMID 9723859. 
  • Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation 5 (3-4): 184–92. doi:10.1159/000026336. PMID 9730685. 
  • Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179. 
  • Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712. 
  • Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M et al. (2000). "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF". J. Biol. Chem. 275 (48): 37559–64. doi:10.1074/jbc.M006635200. PMID 10980202. 
  • Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC (2000). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta 1517 (1): 63–72. doi:10.1016/S0167-4781(00)00260-8. PMID 11118617. 
  • Singer AU, Waldo GL, Harden TK, Sondek J (2002). "A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q". Nat. Struct. Biol. 9 (1): 32–6. doi:10.1038/nsb731. PMID 11753430. 
  • Runnels LW, Yue L, Clapham DE (2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371. 
  • Scarlata S (2002). "Regulation of the lateral association of phospholipase Cbeta2 and G protein subunits by lipid rafts". Biochemistry 41 (22): 7092–9. doi:10.1021/bi025625j. PMID 12033943. 
  • Bertagnolo V, Marchisio M, Pierpaoli S, Colamussi ML, Brugnoli F, Visani G et al. (2002). "Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors". J. Leukoc. Biol. 71 (6): 957–65. PMID 12050180. 
  • Barr AJ, Marjoram R, Xu J, Snyderman R (2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3". Biochem. Biophys. Res. Commun. 293 (1): 647–52. doi:10.1016/S0006-291X(02)00259-0. PMID 12054652. 
  • Buck E, Schatz P, Scarlata S, Iyengar R (2002). "Role of dynamic interactions in effective signal transfer for Gbeta stimulation of phospholipase C-beta 2". J. Biol. Chem. 277 (51): 49707–15. doi:10.1074/jbc.M205553200. PMID 12388553. 
  • Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2002). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.