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Phospholipase C, beta 2
Protein PLCB2 PDB 2fju.png
PDB rendering based on 2fju.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PLCB2 ; PLC-beta-2
External IDs OMIM604114 MGI107465 HomoloGene20957 ChEMBL: 3620 GeneCards: PLCB2 Gene
EC number
RNA expression pattern
PBB GE PLCB2 204046 at tn.png
More reference expression data
Species Human Mouse
Entrez 5330 18796
Ensembl ENSG00000137841 ENSMUSG00000040061
UniProt Q00722 A3KGF7
RefSeq (mRNA) NM_001284297 NM_001290790
RefSeq (protein) NP_001271226 NP_001277719
Location (UCSC) Chr 15:
40.57 – 40.6 Mb
Chr 2:
118.71 – 118.73 Mb
PubMed search [1] [2]

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.[1][2][3] The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.


PLCB2 has been shown to interact with MAP2K3[4] and TRPM7.[5]


  1. ^ Park D, Jhon DY, Kriz R, Knopf J, Rhee SG (Sep 1992). "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2". J Biol Chem 267 (23): 16048–55. PMID 1644792. 
  2. ^ Park SH, Ryu SH, Suh PG, Kim H (Mar 1999). "Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization". Cytogenet Cell Genet 83 (1–2): 48–9. doi:10.1159/000015166. PMID 9925923. 
  3. ^ "Entrez Gene: PLCB2 phospholipase C, beta 2". 
  4. ^ Barr, Alastair J; Marjoram Robin; Xu Jing; Snyderman Ralph (Apr 2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3". Biochem. Biophys. Res. Commun. (United States) 293 (1): 647–52. doi:10.1016/S0006-291X(02)00259-0. ISSN 0006-291X. PMID 12054652. 
  5. ^ Runnels, Loren W; Yue Lixia; Clapham David E (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. (England) 4 (5): 329–36. doi:10.1038/ncb781. ISSN 1465-7392. PMID 11941371. 

Further reading[edit]