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Phospholipase C, beta 3 (phosphatidylinositol-specific)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol PLCB3
External IDs OMIM600230 MGI104778 HomoloGene47960 ChEMBL: 5449 GeneCards: PLCB3 Gene
EC number
RNA expression pattern
PBB GE PLCB3 213384 x at tn.png
More reference expression data
Species Human Mouse
Entrez 5331 18797
Ensembl ENSG00000149782 ENSMUSG00000024960
UniProt Q01970 P51432
RefSeq (mRNA) NM_000932 NM_001290349
RefSeq (protein) NP_000923 NP_001277278
Location (UCSC) Chr 11:
64.02 – 64.04 Mb
Chr 19:
6.95 – 6.97 Mb
PubMed search [1] [2]

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.[1][2] The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.


PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.[3]


  1. ^ Weber G, Friedman E, Grimmond S, Hayward NK, Phelan C, Skogseid B, Gobl A, Zedenius J, Sandelin K, Teh BT, et al. (March 1995). "The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours". Hum Mol Genet 3 (10): 1775–81. doi:10.1093/hmg/3.10.1775. PMID 7849701. 
  2. ^ "Entrez Gene: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)". 
  3. ^ Hwang, J I; Heo K; Shin K J; Kim E; Yun C; Ryu S H; Shin H S; Suh P G (June 2000). "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2". J. Biol. Chem. (UNITED STATES) 275 (22): 16632–7. doi:10.1074/jbc.M001410200. ISSN 0021-9258. PMID 10748023. 

Further reading[edit]

  • Carozzi AJ, Kriz RW, Webster C, Parker PJ (1993). "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily.". Eur. J. Biochem. 210 (2): 521–9. doi:10.1111/j.1432-1033.1992.tb17450.x. PMID 1333955. 
  • Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339. 
  • Zauli G, Previati M, Caramelli E, et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147. 
  • Lagercrantz J, Carson E, Phelan C, et al. (1995). "Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3).". Genomics 26 (3): 467–72. doi:10.1016/0888-7543(95)80164-H. PMID 7607669. 
  • Mazuruk K, Schoen TJ, Chader GJ, Rodriguez IR (1995). "Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene.". Biochem. Biophys. Res. Commun. 212 (1): 190–5. doi:10.1006/bbrc.1995.1955. PMID 7612006. 
  • Sinke RJ, Geurts van Kessel AG (1995). "Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13.". Genomics 25 (2): 568–9. doi:10.1016/0888-7543(95)80060-Y. PMID 7789993. 
  • Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385. 
  • Snow BE, Hall RA, Krumins AM, et al. (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.". J. Biol. Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375. 
  • Wang S, Zhou Y, Lukinius A, et al. (1998). "Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3.". Biochim. Biophys. Acta 1393 (1): 173–8. doi:10.1016/s0005-2760(98)00074-5. PMID 9714794. 
  • Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3-4): 184–92. doi:10.1159/000026336. PMID 9730685. 
  • Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179. 
  • Hwang JI, Heo K, Shin KJ, et al. (2000). "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2.". J. Biol. Chem. 275 (22): 16632–7. doi:10.1074/jbc.M001410200. PMID 10748023. 
  • Wang JC, Waltner-Law M, Yamada K, et al. (2000). "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.". J. Biol. Chem. 275 (24): 18418–23. doi:10.1074/jbc.M910211199. PMID 10748198. 
  • Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712. 
  • Caricasole A, Sala C, Roncarati R, et al. (2001). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).". Biochim. Biophys. Acta 1517 (1): 63–72. doi:10.1016/S0167-4781(00)00260-8. PMID 11118617. 
  • Stålberg P, Lopez-Egido JR, Wang S, et al. (2001). "Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene.". Biochem. Biophys. Res. Commun. 281 (1): 227–31. doi:10.1006/bbrc.2001.4329. PMID 11178984. 
  • Xia C, Bao Z, Yue C, et al. (2001). "Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases.". J. Biol. Chem. 276 (23): 19770–7. doi:10.1074/jbc.M006266200. PMID 11278298. 
  • Yue C, Sanborn BM (2001). "KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser.". Mol. Cell. Endocrinol. 175 (1-2): 149–56. doi:10.1016/S0303-7207(01)00383-5. PMID 11325525. 
  • Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.