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Phospholipase C, beta 4
Symbols PLCB4 ; ARCND2; PI-PLC
External IDs OMIM600810 MGI107464 HomoloGene8471 IUPHAR: 1406 ChEMBL: 2751 GeneCards: PLCB4 Gene
EC number
RNA expression pattern
PBB GE PLCB4 203895 at tn.png
PBB GE PLCB4 203896 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5332 18798
Ensembl ENSG00000101333 ENSMUSG00000039943
UniProt Q15147 A2AT91
RefSeq (mRNA) NM_000933 NM_013829
RefSeq (protein) NP_000924 NP_038857
Location (UCSC) Chr 20:
9.05 – 9.46 Mb
Chr 2:
135.66 – 136.01 Mb
PubMed search [1] [2]

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 is an enzyme that in humans is encoded by the PLCB4 gene.[1][2]


The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Two transcript variants encoding different isoforms have been found for this gene.[2]


  1. ^ Alvarez RA, Ghalayini AJ, Xu P, Hardcastle A, Bhattacharya S, Rao PN, Pettenati MJ, Anderson RE, Baehr W (Feb 1996). "cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4)". Genomics 29 (1): 53–61. doi:10.1006/geno.1995.1214. PMID 8530101. 
  2. ^ a b "Entrez Gene: PLCB4 phospholipase C, beta 4". 

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