PLCD3

Phospholipase C, delta 3
Identifiers
Symbols	PLCD3; MGC71172
External IDs	OMIM: 608795 MGI: 107451 HomoloGene: 14858 GeneCards: PLCD3 Gene
EC number	3.1.4.11
Gene Ontology Molecular function • phosphatidylinositol phospholipase C activity • signal transducer activity • calcium ion binding • hydrolase activity Cellular component • cytoplasm • membrane • cleavage furrow Biological process • angiogenesis • lipid catabolic process • intracellular signal transduction • regulation of cell proliferation • labyrinthine layer blood vessel development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	113026	72469
Ensembl	ENSG00000161714	ENSMUSG00000020937
UniProt	Q8N3E9	Q8K2J0
RefSeq (mRNA)	NM_133373	NM_152813.3
RefSeq (protein)	NP_588614	NP_690026.2
Location (UCSC)	Chr 17: 43.19 – 43.21 Mb	Chr 11: 102.93 – 102.96 Mb
PubMed search	[1]	[2]

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene.A lot of plcd3 express to the brain.

Function

This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. PLCd3 is most similar to PLCd1. PLCd3 plays important roles in normal development of the placenta.

Further reading

• Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=329852. 
• Zauli G, Previati M, Caramelli E, et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147. 
• Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385. 
• Pawełczyk T, Matecki A (1998). "Expression, purification and kinetic properties of human recombinant phospholipase C delta 3.". Acta Biochim. Pol. 44 (2): 221–9. PMID 9360711. 
• Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685. 
• Pawelczyk T, Matecki A (1998). "Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium.". Eur. J. Biochem. 257 (1): 169–77. doi:10.1046/j.1432-1327.1998.2570169.x. PMID 9799116. 
• Pawelczyk T, Matecki A (1999). "Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes.". Eur. J. Biochem. 262 (2): 291–8. doi:10.1046/j.1432-1327.1999.00388.x. PMID 10336610. 
• Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179. 
• Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538–42. PMID 10843712. 
• Lin FG, Cheng HF, Lee IF, et al. (2001). "Downregulation of phospholipase C delta3 by cAMP and calcium.". Biochem. Biophys. Res. Commun. 286 (2): 274–80. doi:10.1006/bbrc.2001.5371. PMID 11500033. 
• Ananthanarayanan B, Das S, Rhee SG, et al. (2002). "Membrane targeting of C2 domains of phospholipase C-delta isoforms.". J. Biol. Chem. 277 (5): 3568–75. doi:10.1074/jbc.M109705200. PMID 11706040. 
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669. 
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.