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Phospholipase C, delta 3
Symbols PLCD3 ; PLC-delta-3
External IDs OMIM608795 MGI107451 HomoloGene14858 ChEMBL: 2965 GeneCards: PLCD3 Gene
EC number
Species Human Mouse
Entrez 113026 72469
Ensembl ENSG00000161714 ENSMUSG00000020937
UniProt Q8N3E9 Q8K2J0
RefSeq (mRNA) NM_133373 NM_152813
RefSeq (protein) NP_588614 NP_690026
Location (UCSC) Chr 17:
43.19 – 43.21 Mb
Chr 11:
103.07 – 103.1 Mb
PubMed search [1] [2]

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene.[1][2][3]A lot of plcd3 express to the brain.


This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.[3] PLCd3 is most similar to PLCd1. PLCd3 plays important roles in normal development of the placenta.


  1. ^ Kim H, Suh PG, Ryu SH, Park SH (Apr 2000). "Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization". Cytogenet Cell Genet 87 (3–4): 209–10. doi:10.1159/000015469. PMID 10702670. 
  2. ^ Ghosh S, Pawelczyk T, Lowenstein JM (Jun 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expr Purif 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492. 
  3. ^ a b "Entrez Gene: PLCD3 phospholipase C, delta 3". 

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