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Phospholipase C, epsilon 1
Protein PLCE1 PDB 2bye.png
PDB rendering based on 2bye.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM608414 MGI1921305 HomoloGene9478 ChEMBL: 3282 GeneCards: PLCE1 Gene
EC number
RNA expression pattern
PBB GE PLCE1 205111 s at tn.png
PBB GE PLCE1 205112 at tn.png
More reference expression data
Species Human Mouse
Entrez 51196 74055
Ensembl ENSG00000138193 ENSMUSG00000024998
UniProt Q9P212 Q8K4S1
RefSeq (mRNA) NM_001165979 NM_019588
RefSeq (protein) NP_001159451 NP_062534
Location (UCSC) Chr 10:
95.75 – 96.09 Mb
Chr 19:
38.52 – 38.79 Mb
PubMed search [1] [2]

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 is an enzyme that in humans is encoded by the PLCE1 gene.[1][2][3]


PLCE1 belongs to the phospholipase family that catalyzes the hydrolysis of polyphosphoinositides such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) to generate the second messengers Ins(1,4,5)P3 and diacylglycerol. These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression.[supplied by OMIM][3]


  1. ^ Lopez I, Mak EC, Ding J, Hamm HE, Lomasney JW (May 2001). "A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway". J Biol Chem 276 (4): 2758–65. doi:10.1074/jbc.M008119200. PMID 11022047. 
  2. ^ Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T (May 2001). "Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras". J Biol Chem 276 (4): 2752–7. doi:10.1074/jbc.M008324200. PMID 11022048. 
  3. ^ a b "Entrez Gene: PLCE1 phospholipase C, epsilon 1". 

Further reading[edit]