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Phospholipase C, gamma 1
Protein PLCG1 PDB 1hsq.png
PDB rendering based on 1hsq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PLCG1 ; NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1
External IDs OMIM172420 MGI97615 HomoloGene1997 ChEMBL: 3964 GeneCards: PLCG1 Gene
EC number
RNA expression pattern
PBB GE PLCG1 202789 at tn.png
PBB GE PLCG1 216551 x at tn.png
More reference expression data
Species Human Mouse
Entrez 5335 18803
Ensembl ENSG00000124181 ENSMUSG00000016933
UniProt P19174 Q62077
RefSeq (mRNA) NM_002660 NM_021280
RefSeq (protein) NP_002651 NP_067255
Location (UCSC) Chr 20:
39.77 – 39.81 Mb
Chr 2:
160.73 – 160.78 Mb
PubMed search [1] [2]

Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene.[1][2]


The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RASGRP1 to translocate to the Golgi apparatus, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. The receptor protein tyrosine phosphatase PTPmu (PTPRM) is capable of dephosphorylating PLCG1.[3] Two transcript variants encoding different isoforms have been found for this gene.[4]

Clinical significance[edit]

Researchers studying PLCg1 and its role in breast cancer metastasis discovered this gene can promote cancer metastasis and subsequently blocking it stopped cancer from spreading. Research is ongoing but this gene could lead to the development of new anti-cancer drugs.[5][6]


PLCG1 has been shown to interact with:

See also[edit]


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