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Phospholipase C, gamma 2 (phosphatidylinositol-specific)
Protein PLCG2 PDB 2K2J.png
Rendering based on PDB 2K2J.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PLCG2 ; APLAID; FCAS3; PLC-IV; PLC-gamma-2
External IDs OMIM600220 MGI97616 HomoloGene55671 ChEMBL: 4100 GeneCards: PLCG2 Gene
EC number
RNA expression pattern
PBB GE PLCG2 204613 at tn.png
More reference expression data
Species Human Mouse
Entrez 5336 234779
Ensembl ENSG00000197943 ENSMUSG00000034330
UniProt P16885 Q8CIH5
RefSeq (mRNA) NM_002661 NM_172285
RefSeq (protein) NP_002652 NP_758489
Location (UCSC) Chr 16:
81.77 – 81.99 Mb
Chr 8:
117.5 – 117.64 Mb
PubMed search [1] [2]

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an enzyme that in humans is encoded by the PLCG2 gene.[1][2]


Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM][2]


PLCG2 has been shown to interact with PTPN11,[3] LYN,[4][5] Bruton's tyrosine kinase,[5][6] SHC1[3][7] and GAB2.[3]


  1. ^ Hernandez D, Egan SE, Yulug IG, Fisher EM (February 1995). "Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse". Genomics 23 (2): 504–7. doi:10.1006/geno.1994.1533. PMID 7835906. 
  2. ^ a b "Entrez Gene: PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)". 
  3. ^ a b c Boudot, Cédric; Kadri Zahra; Petitfrère Emmanuelle; Lambert Elise; Chrétien Stany; Mayeux Patrick; Haye Bernard; Billat Claudine (October 2002). "Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells". Cell. Signal. (England) 14 (10): 869–78. doi:10.1016/S0898-6568(02)00036-0. ISSN 0898-6568. PMID 12135708. 
  4. ^ Pleiman, C M; Clark M R; Gauen L K; Winitz S; Coggeshall K M; Johnson G L; Shaw A S; Cambier J C (September 1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. (UNITED STATES) 13 (9): 5877–87. ISSN 0270-7306. PMC 360336. PMID 8395016. 
  5. ^ a b Guo, B; Kato R M; Garcia-Lloret M; Wahl M I; Rawlings D J (August 2000). "Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex". Immunity (UNITED STATES) 13 (2): 243–53. doi:10.1016/S1074-7613(00)00024-8. ISSN 1074-7613. PMID 10981967. 
  6. ^ Yasuda, Tomoharu; Tezuka Tohru; Maeda Akito; Inazu Tetsuya; Yamanashi Yuji; Gu Hua; Kurosaki Tomohiro; Yamamoto Tadashi (July 2002). "Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells". J. Exp. Med. (United States) 196 (1): 51–63. doi:10.1084/jem.20020068. ISSN 0022-1007. PMC 2194016. PMID 12093870. 
  7. ^ Perskvist, N; Zheng L; Stendahl O (January 2000). "Activation of human neutrophils by Mycobacterium tuberculosis H37Ra involves phospholipase C gamma 2, Shc adapter protein, and p38 mitogen-activated protein kinase". J. Immunol. (UNITED STATES) 164 (2): 959–65. doi:10.4049/jimmunol.164.2.959. ISSN 0022-1767. PMID 10623845. 

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