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Pleckstrin 2
Protein PLEK2 PDB 1v3f.png
PDB rendering based on 1v3f.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol PLEK2
External IDs OMIM608007 MGI1351466 HomoloGene8447 GeneCards: PLEK2 Gene
RNA expression pattern
PBB GE PLEK2 218644 at tn.png
More reference expression data
Species Human Mouse
Entrez 26499 27260
Ensembl ENSG00000100558 ENSMUSG00000021118
UniProt Q9NYT0 Q9WV52
RefSeq (mRNA) NM_016445 NM_013738
RefSeq (protein) NP_057529 NP_038766
Location (UCSC) Chr 14:
67.85 – 67.88 Mb
Chr 12:
78.89 – 78.91 Mb
PubMed search [1] [2]

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene.[1][2][3] The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.[4]


  1. ^ Lemmon MA, Ferguson KM, Abrams CS (Mar 2002). "Pleckstrin homology domains and the cytoskeleton". FEBS Lett 513 (1): 71–6. doi:10.1016/S0014-5793(01)03243-4. PMID 11911883. 
  2. ^ Hamaguchi N, Ihara S, Ohdaira T, Nagano H, Iwamatsu A, Tachikawa H, Fukui Y (Aug 2007). "Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading". Biochem Biophys Res Commun 361 (2): 270–5. doi:10.1016/j.bbrc.2007.06.132. PMID 17658464. 
  3. ^ "Entrez Gene: PLEK2 pleckstrin 2". 
  4. ^ "AceView: PLEK2 gene". AceView. National Library of Medicine. Retrieved 24 April 2011. 

Further reading[edit]