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Pleckstrin homology domain containing, family O member 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PLEKHO1 ; CKIP-1; OC120
External IDs OMIM608335 MGI1914470 HomoloGene9448 GeneCards: PLEKHO1 Gene
RNA expression pattern
PBB GE PLEKHO1 218223 s at tn.png
More reference expression data
Species Human Mouse
Entrez 51177 67220
Ensembl ENSG00000023902 ENSMUSG00000015745
UniProt Q53GL0 Q9JIY0
RefSeq (mRNA) NM_016274 NM_023320
RefSeq (protein) NP_057358 NP_075809
Location (UCSC) Chr 1:
150.12 – 150.14 Mb
Chr 3:
95.99 – 96 Mb
PubMed search [1] [2]

Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the PLEKHO1 gene.[1][2]


PLEKHO1 has been shown to interact with Casein kinase 2, alpha 1[1] and SMURF1.[3]


  1. ^ a b Bosc DG, Graham KC, Saulnier RB, Zhang C, Prober D, Gietz RD, Litchfield DW (Jun 2000). "Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2". J Biol Chem 275 (19): 14295–306. doi:10.1074/jbc.275.19.14295. PMID 10799509. 
  2. ^ "Entrez Gene: PLEKHO1 pleckstrin homology domain containing, family O member 1". 
  3. ^ Lu, Kefeng; Yin Xiushan; Weng Tujun; Xi Shenli; Li Li; Xing Guichun; Cheng Xuan; Yang Xiao; Zhang Lingqiang; He Fuchu (Aug 2008). "Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1". Nat. Cell Biol. (England) 10 (8): 994–1002. doi:10.1038/ncb1760. PMID 18641638. 

Further reading[edit]